Literature DB >> 33791988

Metabolomics of Glioma.

Sizhe Feng1, Yutong Liu2.   

Abstract

Metabolic reprogramming is an important characteristics of glioma, the most common form of malignant brain tumor. In this chapter, we aim to discuss some of the recently discovered metabolic alterations in glioma, including the dysregulated TCA cycle, amino acid, nucleotide, and lipid metabolism. We have also detailed some of the metabolomic applications in gliomas, particularly the analyses of body fluids and tissues of glioma patients. With new improvement of the technology, metabolomics will become a powerful tool to discover truly meaningful biomarkers for clinical applications in gliomas. Metabolomic studies of gliomas will also facilitate a better understanding of the molecular targets/pathways and the development of new therapeutic treatments for this devastating disease.

Entities:  

Keywords:  Glioma; IDH gene mutation; Metabolite biomarker; Metabolomics

Mesh：

Substances：

Year:  2021        PMID： 33791988     DOI： 10.1007/978-3-030-51652-9_18

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  74 in total

Review 1.  European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas.

Authors:  Michael Weller; Martin van den Bent; Jörg C Tonn; Roger Stupp; Matthias Preusser; Elizabeth Cohen-Jonathan-Moyal; Roger Henriksson; Emilie Le Rhun; Carmen Balana; Olivier Chinot; Martin Bendszus; Jaap C Reijneveld; Frederick Dhermain; Pim French; Christine Marosi; Colin Watts; Ingela Oberg; Geoffrey Pilkington; Brigitta G Baumert; Martin J B Taphoorn; Monika Hegi; Manfred Westphal; Guido Reifenberger; Riccardo Soffietti; Wolfgang Wick
Journal:  Lancet Oncol       Date:  2017-05-05       Impact factor: 41.316

2.  Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.

Authors:  Isaac Marin-Valencia; Chendong Yang; Tomoyuki Mashimo; Steve Cho; Hyeonman Baek; Xiao-Li Yang; Kartik N Rajagopalan; Melissa Maddie; Vamsidhara Vemireddy; Zhenze Zhao; Ling Cai; Levi Good; Benjamin P Tu; Kimmo J Hatanpaa; Bruce E Mickey; José M Matés; Juan M Pascual; Elizabeth A Maher; Craig R Malloy; Ralph J Deberardinis; Robert M Bachoo
Journal:  Cell Metab       Date:  2012-06-06       Impact factor: 27.287

3.  Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Authors:  Tomoyuki Mashimo; Kumar Pichumani; Vamsidhara Vemireddy; Kimmo J Hatanpaa; Dinesh Kumar Singh; Shyam Sirasanagandla; Suraj Nannepaga; Sara G Piccirillo; Zoltan Kovacs; Chan Foong; Zhiguang Huang; Samuel Barnett; Bruce E Mickey; Ralph J DeBerardinis; Benjamin P Tu; Elizabeth A Maher; Robert M Bachoo
Journal:  Cell       Date:  2014-12-18       Impact factor: 41.582

4.  Investigation on signal transduction pathways after H(1) receptor activated by histamine in C6 glioma cells: involvement of phosphatidylinositol and arachidonic acid metabolisms.

Authors:  Chin-Lu Tseng; Jiann-Wu Wei
Journal:  J Chin Med Assoc       Date:  2012-03-31       Impact factor: 2.743

5.  Biochemical analysis and solubilization of central alpha 1-adrenoceptors in the rat.

Authors:  P Guicheney; A Rappaport; P Meyer
Journal:  Chest       Date:  1983-02       Impact factor: 9.410

6.  Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy.

Authors:  Chetan Goudar; Richard Biener; C Boisart; Rüdiger Heidemann; James Piret; Albert de Graaf; Konstantin Konstantinov
Journal:  Metab Eng       Date:  2009-11-05       Impact factor: 9.783

7.  An integrated genomic analysis of human glioblastoma multiforme.

Authors:  D Williams Parsons; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis A Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nick Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728

Review 8.  Isocitrate dehydrogenase-mutant glioma: Evolving clinical and therapeutic implications.

Authors:  Julie J Miller; Helen A Shih; Ovidiu C Andronesi; Daniel P Cahill
Journal:  Cancer       Date:  2017-10-05       Impact factor: 6.860

Review 9.  Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.

Authors:  Zachary J Reitman; Hai Yan
Journal:  J Natl Cancer Inst       Date:  2010-05-31       Impact factor: 11.816

Review 10.  Biological Role and Therapeutic Potential of IDH Mutations in Cancer.

Authors:  Matthew S Waitkus; Bill H Diplas; Hai Yan
Journal:  Cancer Cell       Date:  2018-05-24       Impact factor: 38.585
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  3 in total

1.  Deep Convolutional Neural Network-Based Brain Magnetic Resonance Imaging Applied in Glioma Diagnosis and Tumor Region Identification.

Authors:  Zhen Chen; Ning Li; Changtao Liu; Shiwei Yan
Journal:  Contrast Media Mol Imaging       Date:  2022-05-24       Impact factor: 3.009

2.  Metabolic Characteristics and M2 Macrophage Infiltrates in Invasive Nonfunctioning Pituitary Adenomas.

Authors:  Kunzhe Lin; Jianping Zhang; Yinghong Lin; Zhijie Pei; Shousen Wang
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-08       Impact factor: 6.055

3.  Development and validation of cuproptosis-associated prognostic signatures in WHO 2/3 glioma.

Authors:  Zhang Ye; Shenqi Zhang; Jiayang Cai; Liguo Ye; Lun Gao; Yixuan Wang; Shiao Tong; Qian Sun; Yu Wu; Xiaoxing Xiong; Qianxue Chen
Journal:  Front Oncol       Date:  2022-08-18       Impact factor: 5.738
  3 in total

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