Literature DB >> 33791984

NMR-Based Metabolomics in Cancer Research.

Rui Hu1, Tao Li1,2, Yunhuang Yang1, Yuan Tian3,4, Limin Zhang1.   

Abstract

Nuclear magnetic resonance (NMR) spectroscopy offers reproducible quantitative analysis and structural identification of metabolites in various complex biological samples, such as biofluids (plasma, serum, and urine), cells, tissue extracts, and even intact organs. Therefore, NMR-based metabolomics, a mainstream metabolomic platform, has been extensively applied in many research fields, including pharmacology, toxicology, pathophysiology, nutritional intervention, disease diagnosis/prognosis, and microbiology. In particular, NMR-based metabolomics has been successfully used for cancer research to investigate cancer metabolism and identify biomarker and therapeutic targets. This chapter highlights the innovations and challenges of NMR-based metabolomics platform and its applications in cancer research.

Entities:  

Keywords:  Cancer metabolomics; Data analysis; Microcoil NMR; Nuclear magnetic resonance (NMR); Sample preparation

Mesh：

Substances：

Year:  2021        PMID： 33791984     DOI： 10.1007/978-3-030-51652-9_14

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  89 in total

1.  Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells.

Authors:  E Ackerstaff; B R Pflug; J B Nelson; Z M Bhujwalla
Journal:  Cancer Res       Date:  2001-05-01       Impact factor: 12.701

2.  High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues.

Authors:  Olaf Beckonert; Muireann Coen; Hector C Keun; Yulan Wang; Timothy M D Ebbels; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Journal:  Nat Protoc       Date:  2010-05-13       Impact factor: 13.491

3.  Strategy for choosing extraction procedures for NMR-based metabolomic analysis of mammalian cells.

Authors:  Estelle Martineau; Illa Tea; Gregory Loaëc; Patrick Giraudeau; Serge Akoka
Journal:  Anal Bioanal Chem       Date:  2011-08-13       Impact factor: 4.142

4.  High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study.

Authors:  Richard H Barton; Jeremy K Nicholson; Paul Elliott; Elaine Holmes
Journal:  Int J Epidemiol       Date:  2008-04       Impact factor: 7.196

5.  Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification.

Authors:  Judith M Fonville; Anthony D Maher; Muireann Coen; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Journal:  Anal Chem       Date:  2010-03-01       Impact factor: 6.986

6.  Global metabolic profiling of animal and human tissues via UPLC-MS.

Authors:  Elizabeth J Want; Perrine Masson; Filippos Michopoulos; Ian D Wilson; Georgios Theodoridis; Robert S Plumb; John Shockcor; Neil Loftus; Elaine Holmes; Jeremy K Nicholson
Journal:  Nat Protoc       Date:  2012-12-06       Impact factor: 13.491

7.  Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy.

Authors:  Leo L Cheng; Melissa A Burns; Jennifer L Taylor; Wenlei He; Elkan F Halpern; W Scott McDougal; Chin-Lee Wu
Journal:  Cancer Res       Date:  2005-04-15       Impact factor: 12.701

8.  Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.

Authors:  Bagganahalli S Somashekar; Pachiyappan Kamarajan; Theodora Danciu; Yvonne L Kapila; Arul M Chinnaiyan; Thekkelnaycke M Rajendiran; Ayyalusamy Ramamoorthy
Journal:  J Proteome Res       Date:  2011-10-18       Impact factor: 4.466

9.  Quantitative metabolomic profiling of serum and urine in DSS-induced ulcerative colitis of mice by (1)H NMR spectroscopy.

Authors:  Rudolf Schicho; Alsu Nazyrova; Rustem Shaykhutdinov; Gavin Duggan; Hans J Vogel; Martin Storr
Journal:  J Proteome Res       Date:  2010-10-28       Impact factor: 4.466

Review 10.  The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy.

Authors:  Yaojie Fu; Shanshan Liu; Shanghelin Yin; Weihong Niu; Wei Xiong; Ming Tan; Guiyuan Li; Ming Zhou
Journal:  Oncotarget       Date:  2017-05-25
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