Wen Song1,2, Yue Wang1,2, Fengming Tian1,2, Liang Ge3, Xiaoqian Shang1,2, Qiang Zeng1,2, Ning Feng2, Jiahui Fan1,2, Jing Wang1,2,4, Xiumin Ma1,2. 1. State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, 830000, China. 2. First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China. 3. The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China. 4. Respiratory Department of the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570000, China.
Abstract
BACKGROUND: Currently, standards of antibiotic use in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients are controversial. OBJECTIVE: The aim of the present study was to analyze the value of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) levels to guide the antibiotic treatment of AECOPD patients. METHODS: A total of 371 patients with COPD or AECOPD were included in the study. Clinical and laboratory data were obtained at admission, 325 AECOPD patients and 46 sCOPD patients treated with antibiotics. The receiver operating curve (ROC) was used to evaluate the relationship between CRP, PCT, and IL-6. RESULTS: This study included medical record/case control 1, the COPD group (n = 46) and the AECOPD group (n = 325), and medical record control 2, the nonchanged antibiotic group (n = 203) and the changed antibiotic group (n = 61). In case 1, CRP, PCT, and IL-6 levels in the AECOPD group were higher than that in the control group (P < 0.05), while the result of ROC showed that IL-6 had higher AUC values (0.773) and higher sensitivity (71.7%) than other indicators. The specificity of PCT (93.5%) is higher than other indicators. In case 2, ROC curve results showed that the AUC value of IL-6 (0.771) was slightly higher than PCT and CRP. The sensitivity (85.2%) and specificity (65.5%) of CRP were higher than other indicators. CONCLUSIONS: IL-6 and PCT were elevated in AECOPD patients, resulting in a higher diagnostic value for AECOPD. CRP had a higher diagnostic value for antibiotic use in AECOPD patients.
BACKGROUND: Currently, standards of antibiotic use in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients are controversial. OBJECTIVE: The aim of the present study was to analyze the value of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) levels to guide the antibiotic treatment of AECOPD patients. METHODS: A total of 371 patients with COPD or AECOPD were included in the study. Clinical and laboratory data were obtained at admission, 325 AECOPD patients and 46 sCOPD patients treated with antibiotics. The receiver operating curve (ROC) was used to evaluate the relationship between CRP, PCT, and IL-6. RESULTS: This study included medical record/case control 1, the COPD group (n = 46) and the AECOPD group (n = 325), and medical record control 2, the nonchanged antibiotic group (n = 203) and the changed antibiotic group (n = 61). In case 1, CRP, PCT, and IL-6 levels in the AECOPD group were higher than that in the control group (P < 0.05), while the result of ROC showed that IL-6 had higher AUC values (0.773) and higher sensitivity (71.7%) than other indicators. The specificity of PCT (93.5%) is higher than other indicators. In case 2, ROC curve results showed that the AUC value of IL-6 (0.771) was slightly higher than PCT and CRP. The sensitivity (85.2%) and specificity (65.5%) of CRP were higher than other indicators. CONCLUSIONS: IL-6 and PCT were elevated in AECOPD patients, resulting in a higher diagnostic value for AECOPD. CRP had a higher diagnostic value for antibiotic use in AECOPD patients.
Authors: Michele Bartoletti; Massimo Antonelli; Francesco Arturo Bruno Blasi; Ivo Casagranda; Arturo Chieregato; Roberto Fumagalli; Massimo Girardis; Filippo Pieralli; Mario Plebani; Gian Maria Rossolini; Massimo Sartelli; Bruno Viaggi; Pierluigi Viale; Claudio Viscoli; Federico Pea Journal: Clin Chem Lab Med Date: 2018-07-26 Impact factor: 3.694
Authors: Hilde T van der Galiën; Erik A H Loeffen; Karin G E Miedema; Wim J E Tissing Journal: Support Care Cancer Date: 2018-05-19 Impact factor: 3.603