Jae Hwi Choi1, See Min Choi1,2,3, Sin Woo Lee1, Seong Uk Jeh1,2,3, Jae Seog Hyun1,2,3, Min Ho Lee4, Chunwoo Lee4, Sung Chul Kam2,3,4, Dong Chul Kim2,3,5, Jong Sil Lee2,3,5, Jeong Seok Hwa6,2,3. 1. Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea. 2. Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea. 3. Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea. 4. Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea. 5. Department of Pathology, Gyeongsang National University Hospital, Jinju, Republic of Korea. 6. Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea; seogee@gnu.ac.kr.
Abstract
BACKGROUND/AIM: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). MATERIALS AND METHODS: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. RESULTS: ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. CONCLUSION: AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.
BACKGROUND/AIM: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). MATERIALS AND METHODS: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. RESULTS: ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. CONCLUSION:AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.