| Literature DB >> 33788112 |
A M Vorob'ev1, M N Anurova2, A V Aleshkin3, V A Gushchin4, D V Vasina4, N P Antonova4, I A Kiseleva3, E O Rubalskii3, E R Zul'karneev3,5, A I Laishevtsev5,6, E R Mekhtiev3, V V Kaminskii3, E O Bakhrushina2, S S Bochkareva3, A V Karaulov3,2.
Abstract
The bactericidal activity of recombinant endolysins LysECD7, LysAm24, LysAp22, LysSi3 and LysSt11 was assayed in multidrug resistant strains (n=120) of Salmonella enterica, E. coli, Acinetobacter baumannii, Enterobacter spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, and Campylobacter jejuni. The assay showed that the recombinant endolysins had a wide spectrum of bactericidal activity compared to endolysins of their progenitor phages. Among examined endolysins, we selected the active pharmaceutical substances with broad spectrum of bactericidal activity. Most strains were sensitive to LysECD7 (70.7%), LysAm24 (65%), and LysAp22 (58.6%), which seems to be promising causative agents for the development of finished dosage form.Entities:
Keywords: bacteriophages; endolysins; multidrug resistant bacterial strains; strength and spectrum of bactericidal activity
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Year: 2021 PMID： 33788112 DOI： 10.1007/s10517-021-05122-6
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804