Study of Hematological Parameters and Morphometric Indices of Erythrocytes in Rats Exposed to Calcium Oxide Nanoparticles.

In female Wistar rats, we studied the effects of daily 20-day administration of intragastric suspension of nanosized calcium oxide on hematological indices (the counts of erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, basophils, lymphocytes, monocytes, stab/segmented neutrophils, and the eosinophil-to-lymphocyte ratio) and morphometric parameters of erythrocytes (equivalent Feret's diameter, sphericity, aspect ratio, and convexity). The study revealed significantly (up to 3.1 times) decreased levels of hemoglobin, platelets, hematocrit, averaged content of hemoglobin in erythrocyte, and platelet volume relatively to the control values. The established morphometric parameters of blood erythrocytes attested to predominance of spherocytes, which can be regarded as systemic response of the body to calcium oxide nanoparticles fraught with possible deterioration of perfusion in microvasculature and hypoxia in the tissues.