Literature DB >> 33788102

Effect of Liposome-Encapsulated Dextrazide on Local Regulation of Extracellular Matrix Metabolism in Liver and Lungs of Mice with during Chronic BCG-Induced Granulomatosis.

L B Kim1, A N Putyatina2, G S Russkikh2, V A Shkurupy2,3.   

Abstract

The liposomal form of isonicotinic acid hydrazide conjugate with oxidized dextran (liposomeencapsulated dextrazide, LEDZ) injected intraperitoneally for 3 months to BALB/c mice with chronic BCG-induced granulomatosis (6 month after infection) down-regulated activities of protease (MMP) and antiprotease (TIMP-1, TIMP-2, α2-macroglobulin) components of the regulation system, which indicates a drop of destructive and inflammatory potential of BCGinduced granulomatosis. The persistent enhanced hyaluronidase activity in the liver and its reduced (normalized to control level) activity in the lungs after administration of LEDZ indicates a greater hydrolysis of hyaluronan in the liver than in the lungs. LEDZ-induced changes in MMP/TIMP system in mouse liver and lungs are characterized with relative elevation of protease activity over that of antiprotease one.

Entities:  

Keywords:  BCG-granulomatosis; hyaluronidase activity; liposome-encapsulated dextrazide; system ММP/ТIMP; α2-macroglobulin

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Substances：

Year:  2021        PMID： 33788102     DOI： 10.1007/s10517-021-05123-5

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

Review 1.  Matrix metalloproteinases in tuberculosis.

Authors:  P T Elkington; C A Ugarte-Gil; J S Friedland
Journal:  Eur Respir J       Date:  2011-06-09       Impact factor: 16.671

Review 2.  Alpha-2-macroglobulin as a radioprotective agent: a review.

Authors:  Xueying Chen; Xiangbo Kong; Zhaoqiang Zhang; Wei Chen; Jieyu Chen; Huanyang Li; Wanting Cao; Yaping Ge; Silian Fang
Journal:  Chin J Cancer Res       Date:  2014-10       Impact factor: 5.087

3.  Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.

Authors:  André Kübler; Brian Luna; Christer Larsson; Nicole C Ammerman; Bruno B Andrade; Marlene Orandle; Kevin W Bock; Ziyue Xu; Ulas Bagci; Daniel J Mollura; John Marshall; Jay Burns; Kathryn Winglee; Bintou Ahmadou Ahidjo; Laurene S Cheung; Mariah Klunk; Sanjay K Jain; Nathella Pavan Kumar; Subash Babu; Alan Sher; Jon S Friedland; Paul T G Elkington; William R Bishai
Journal:  J Pathol       Date:  2014-10-06       Impact factor: 7.996

Review 4.  Biochemical and Biological Attributes of Matrix Metalloproteinases.

Authors:  Ning Cui; Min Hu; Raouf A Khalil
Journal:  Prog Mol Biol Transl Sci       Date:  2017-03-22       Impact factor: 3.622

5.  Antifibrotics Effect of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide in Mice with BCG-Induced Granulomatosis Depends on Administration Route.

Authors:  L B Kim; A N Putyatina; G S Russkikh; V A Shkurupy
Journal:  Bull Exp Biol Med       Date:  2020-06-02       Impact factor: 0.804

6.  Effect of Liposomal Delivery of Oxidized Dextran with Isonicotinic Acid Hydrazide on Component Profile of Pulmonary Extracellular Matrix in Mice with BCG-Induced Granulomatosis.

Authors:  L B Kim; A N Putyatina; G S Russkikh; V A Shkurupy
Journal:  Bull Exp Biol Med       Date:  2019-11-28       Impact factor: 0.804

7.  Remodeling of the Extracellular Matrix of the Liver in Mice with BCG-Induced Granulomatosis after Administration of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide.

Authors:  L B Kim; A N Putyatina; G S Russkikh; V A Shkurupy
Journal:  Bull Exp Biol Med       Date:  2019-11-28       Impact factor: 0.804

8.  Fibrogenesis in granulomas and lung interstitium in tuberculous inflammation in mice.

Authors:  V A Shkurupiy; L B Kim; O V Potapova; L A Cherdantseva; A N Putyatina; I K Nikonova
Journal:  Bull Exp Biol Med       Date:  2014-05-03       Impact factor: 0.804

Review 9.  Diverse functions of matrix metalloproteinases during fibrosis.

Authors:  Matthew Giannandrea; William C Parks
Journal:  Dis Model Mech       Date:  2014-02       Impact factor: 5.758

10.  Antimycobacterial drugs modulate immunopathogenic matrix metalloproteinases in a cellular model of pulmonary tuberculosis.

Authors:  Shivani Singh; Andre Kubler; Utpal K Singh; Ajay Singh; Harriet Gardiner; Rajniti Prasad; Paul T Elkington; Jon S Friedland
Journal:  Antimicrob Agents Chemother       Date:  2014-06-02       Impact factor: 5.191
  10 in total

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