| Literature DB >> 33788100 |
E E Genrikhs1, E V Stelmashook1, P D Rogozin1, S V Novikova1, O P Aleksandrova1, V B Sobolev1, V G Skrebitsky1, N K Isaev2,3.
Abstract
The protective effect of antioxidant SkQR1 was examined on the model of left-sided compression ischemia in rat sensorimotor cortex. The special tests aimed to determine the neurologic deficit in the limbs and assess performance of the forelimbs showed that a 2.5-min ischemia produced no disturbance in the limb functions on postsurgery days 1, 3, and 7. Elevation of compression time resulted in neurologic deficit in animals, and its severity depended on this time. A single intravenous injection of SkQR1 (250 nmol/kg body weight) performed 30 min after ischemia significantly reduced the degree of neurologic deficit. In vitro model of ischemia in surviving rat hippocampal slices showed that a 15-min-long ischemia significantly inhibited the population excitatory postsynaptic potentials, which did not restore during reperfusion. Preincubation of the slices with SkQR1 did not significantly affect recovery of these potentials.Entities:
Keywords: acute hippocampal slices; compression ischemia; mitochondrial-targeted antioxidants; neurons; population excitatory postsynaptic potentials (pEPSP)
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Year: 2021 PMID： 33788100 DOI： 10.1007/s10517-021-05112-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804