Literature DB >> 33788099

Peculiarities of Immune Regulation in Men of Perm Region with Atherosclerosis Related to Polymorphism of Candidate Genes.

N A Nikonoshina1, N V Zaitseva1, О V Dolgikh2.   

Abstract

The study examined peculiarities of immune regulation and associated polymorphic variants of candidate genes in men with atherosclerosis in Perm region. The revealed deficiency of CD127 lymphocytes and Annexin V-FITC+7AAD- cells, as well as enhanced level of CD3+CD4+ lymphocytes against the background of variant alleles of candidate genes FAS (rs1159120), CPOX (rs1131857) and wild-type alleles SULT1A1 (rs9282861), MMP9 (rs17576) are responsible for peculiar features of hereditary determination and pathogenesis of atherosclerosis in examined sample (p<0.05). The genetically determined degradation of extracellular matrix in vascular wall and implication of regulated Fas/APO1 apoptosis in the development of progressive atherosclerotic lesions indicate important role of immune system in atherogenesis. The revealed immunological and genetic features are recommended as the markers for early diagnosis of atherosclerosis and its prevention in men of Perm region.

Entities:  

Keywords:  Annexin V-FITC+7AAD— cells; CD127 lymphocytes; atherosclerosis; genetic polymorphism; immune regulation

Mesh：

Substances：

Year:  2021        PMID： 33788099     DOI： 10.1007/s10517-021-05124-4

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

1.  Immunology of atherosclerosis.

Authors:  E Lutgens; C J Binder
Journal:  Thromb Haemost       Date:  2011-10-20       Impact factor: 5.249

2.  SULT1A1 Arg213His polymorphism and lung cancer risk: a meta-analysis.

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Review 3.  Inflammation and atherosclerosis--revisited.

Authors:  Sadip Pant; Abhishek Deshmukh; Guru S Gurumurthy; Naga Venkata Pothineni; Thomas Evans Watts; Francesco Romeo; Jawahar L Mehta
Journal:  J Cardiovasc Pharmacol Ther       Date:  2013-10-31       Impact factor: 2.457

4.  Rosuvastatin induces apoptosis in CD4(+)CD28 (null) T cells in patients with acute coronary syndromes.

Authors:  Andreas Link; Simina Selejan; Lisa Hewera; Felix Walter; Georg Nickenig; Michael Böhm
Journal:  Clin Res Cardiol       Date:  2010-09-19       Impact factor: 5.460

Review 5.  Role of unusual CD4+ CD28- T cells in acute coronary syndrome.

Authors:  Wenjie Sun; Lihui Zheng; Lijuan Huang
Journal:  Mol Biol Rep       Date:  2011-06-22       Impact factor: 2.316

6.  The relationship of circulating endothelial cells to plasma indices of endothelial damage/dysfunction and apoptosis in acute coronary syndromes: implications for prognosis.

Authors:  C J Boos; B Balakrishnan; A D Blann; G Y H Lip
Journal:  J Thromb Haemost       Date:  2008-08-28       Impact factor: 5.824

7.  [Subpopulation Composition of CD4+ T-lymphocytes as Factor Contributing to the Progression of Atherosclerosis of Carotid Arteries].

Authors:  A Yu Filatova; E A Pylaeva; A V Potekhina; A K Osokina; O A Pogorelova; M I Tripoten; T V Balakhonova; S I Provatorov; E A Noeva; E A Klesareva; O I Afanasieva; T I Arefieva
Journal:  Kardiologiia       Date:  2017-04       Impact factor: 0.395

Review 8.  Atherosclerosis: process, indicators, risk factors and new hopes.

Authors:  Mahmoud Rafieian-Kopaei; Mahbubeh Setorki; Monir Doudi; Azar Baradaran; Hamid Nasri
Journal:  Int J Prev Med       Date:  2014-08
  8 in total

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