The Impact of Frailty on the Relationship between Life-Space Mobility and Quality of Life in Older Adults during the COVID-19 Pandemic.

BACKGROUND: The COVID-19 pandemic has led to abrupt restrictions of life-space mobility. The impact of shelter-in-place orders on older adults' health and well-being is still unclear.
OBJECTIVE: To investigate the relationship between life-space mobility and quality of life (QoL) in older adults with and without frailty during the COVID-19 pandemic.
DESIGN: Multicenter prospective cohort study based on structured telephone interviews.
SETTING: Four geriatric outpatient clinics in the metropolitan area of Sao Paulo, Brazil. PARTICIPANTS: 557 community-dwelling adults aged 60 years and older. MEASUREMENTS: The Life-Space Assessment was used to measure community mobility before and during the COVID-19 pandemic, and a previously validated decrease of ≥ 5 points defined restricted life-space mobility. Frailty was assessed through the FRAIL (fatigue, resistance, ambulation, illnesses, and loss of weight) scale. The impact of shelter-in-place orders on QoL was evaluated with the question «How is the COVID-19 pandemic affecting your QoL?», to which participants could respond «not at all», «to some extent», or «to a great extent». We used ordinal logistic regressions to investigate the relationship between restricted life-space mobility and impact on QoL, adjusting our analyses for demographics, frailty, comorbidities, cognition, functionality, loneliness, depression, and anxiety. We explored whether frailty modified the association between life-space mobility and impact on QoL.
RESULTS: Participants were on average 80±8 years old, 65% were women, and 33% were frail. The COVID-19 quarantine led to a restriction of community mobility in 79% of participants and affected the QoL for 77% of participants. We found that restricted life-space mobility was associated with impact on QoL in older adults during the pandemic, although frailty modified the magnitude of the association (P-value for interaction=0.03). Frail participants who experienced restricted life-space mobility had twice the odds of reporting an impact on QoL when compared with non-frail individuals, with respective adjusted odds ratios of 4.20 (95% CI=2.36-7.50) and 2.18 (95% CI=1.33-3.58).
CONCLUSION: Older adults experienced substantial decreases in life-space mobility during the COVID-19 pandemic, and this unexpected change impacted their QoL. Providers should be particularly watchful for the consequences of abrupt life-space restrictions on frail individuals.

Introduction

The COVID-19 pandemic has produced far-reaching effects on health, economy, and behavior all over the world. At the beginning of October 2020, ten months following the first report of COVID-19, about 34 million people have been infected, and more than one million people have died from the disease worldwide (1). Brazil is currently one of the epicenters of the pandemic, following the United States in the number of cases and deaths (1).

Although most people are asymptomatic or oligosymptomatic when infected by the new Coronavirus (SARS-CoV-2), older adults are disproportionately vulnerable to severe forms and death by COVID-19 (2–4). As evidence-based therapeutic measures and vaccines are yet to be developed, most countries have adopted physical distancing as the primary strategy to limit the transmission of the disease (5).

Rigorous distancing can be a powerful weapon to fight the new Coronavirus spread. However, community-dwelling older adults may experience more difficulties in adapting to sudden lifestyle changes, especially in the context of frailty (6, 7). The COVID-19 quarantine has already been associated with the exacerbation of loneliness and psychological distress (8–10), but physical health and well-being can also be affected by the current recommendations. Moreover, freedom and independence to come and go are inherently important to every person and have been recognized as vital determinants of healthy aging (11, 12).

Since mobility is viewed as an essential component of well-being by many older adults, strategies to measure it have been proposed, consolidating the concept of life-space mobility (13, 14). Life-space is characterized by the movement that extends from within one’s home to beyond their town or region, and it can be evaluated by instruments like the Life-Space Assessment (LS A) (15). The LS A is a well-validated tool that measures how much a person moves in the community, maintains social relationships and roles, exploits community amenities, and participates in meaningful activities (12, 13). LSA scores have been shown to predict multiple adverse outcomes (e.g., falls, nursing home admissions, mortality) in community-dwelling older adults (16–22).

Previous studies have demonstrated that declining life-space mobility is associated with lower quality of life (23). However, the artificial and abrupt changes in mobility determined by the COVID-19 pandemic represent an entirely new scenario, and their impact on the health and well-being of older adults with and without frailty is still unknown (24). Therefore, we aimed to investigate whether a sudden decrease in life-space mobility during the COVID-19 pandemic affected the quality of life of older adults. We also explored whether frailty modified the association between life-space mobility and impact on quality of life.

Methods

Study design and participants

This study is an ongoing multicenter prospective cohort study being conducted in the metropolitan area of Sao Paulo, Brazil. Our cohort was recruited to observe the impact of the COVID-19 pandemic on the health trajectories of community-dwelling older adults. Since March 2020, when a statewide quarantine was declared in Sao Paulo, our team of researchers has been working in four geriatric outpatient clinics to follow the mental and physical health of the participants. Three of our study sites [Instituto Central (IC), Instituto do Coracao (InCor), and Instituto do Cancer do Estado de Sao Paulo (ICESP)] belong to the hospital complex of Hospital das Clinicas, University of Sao Paulo Medical School (HCFMUSP), the largest academic medical center in Latin America. HCFMUSP is a tertiary public hospital that provides integrated care for 420,000 older patients residing in the greater Sao Paulo area. Our fourth study site was Hospital do Coracao (HCor), a private philanthropic hospital distinguished in providing patient-centered care for frail older adults in Sao Paulo.

We recruited community-dwelling older adults aged 60 years and over, followed at the four geriatric outpatient clinics. We reviewed electronic databases to identify eligible candidates, using previously recorded information from comprehensive geriatric assessments. We did not invite patients whose database records were incomplete. Long-term facility residents and patients with overt dementia, immobility, or severe dependence in performing activities of daily living (ADLs) were considered ineligible (25). We also excluded candidates who were unable to communicate in the telephone effectively (e.g., hearing loss, aphasia), who could not be reached after three contact attempts, who were hospitalized on the inclusion assessment, and who refused to consent participation.

Written or audio-recorded consent was obtained from participants. Patients who scored 9 points or more in the Patient Health Questionnaire-4 (PHQ-4) were offered additional psychological support following the interviews. Our interviewers also examined signs and symptoms of COVID-19, asked about health services utilization, and reinforced the importance of social distancing and protective measures during the pandemic.

Measurements

In April, we completed detailed telephone interviews to collect baseline information, and the first follow-up assessment from our participants (the follow-up procedures and design of our cohort study are detailed in the Supplementary Figure 1). A team of trained research assistants completed the telephone interviews directly with participants. Medical investigators adjudicated the quality of the collected data. Data were collected and managed using the Research Electronic Data Capture platform (REDCap) (26).

Figure 1

Distribution of the study population in the metropolitan area of Sao Paulo, according to zip code and study site (n=557)

HCor = Hospital do Coracao; IC = Instituto Central; InCor = Instituto do Coracao; ICESP = Instituto do Cancer do Estado de Sao Paulo

Our interviews lasted an average of 20 minutes and included questions on whether the participants were following the news about the COVID-19 pandemic, their concerns about the situation, compliance to measures against contamination, influenza vaccine status, and living arrangements (27). The impact of quarantine on their physical and mental health was evaluated using the following instruments:

International Physical Activity Questionnaire (IPAQ) Short Form (28), a brief questionnaire used to evaluate the frequency and time spent in moderate to vigorous physical activity, including walks, housework, and leisure activities, in a typical week.

Life-Space Assessment (LSA) (29), a self-reported measure of life-space mobility. It estimates the distance traveled over the previous weeks in areas as small as one’s bedroom, up to more distant places in the city or region. LSA also measures the frequency with which each life-space level is attained, and evaluates the independence of movement (i.e., the necessity of an assistive device or assistance from another person). LSA has been validated for telephone application and has scores ranging from 0 to 120, with higher scores indicating greater mobility (15, 30). Previous studies have defined variations of five or more points in LSA scores as significant (13).

3-item UCLA Loneliness Scale (UCLA-3) (31), a three-question scale on «lacking companionship», «feeling left out» and «feeling isolated from others». Responses were scored as 1 (hardly ever), 2 (some of the time), or 3 (often), and a final score was generated from the sum of the items. Participants with scores of ≥6 were defined as having high levels of loneliness.

4-Item Patient Health Questionnaire (PHQ-4) (32), which contains two questions on anxiety symptoms [Generalized Anxiety Disorder 2-item (GAD-2)] and two questions on depressive symptoms [Patient Health Questionnaire 2-item (PHQ-2)]. Each question is answered according to a Likert scale based on how often the symptoms were present in the previous two weeks. The anxiety and depression subscales have scores ranging from 0 to 6, with scores ≥ 3 indicating significant symptoms in the corresponding domain.

In order to assess the impact of the COVID-19 quarantine on their life-space mobility and physical activity levels, we asked participants to complete the LSA and the IPAQ Short Form using two time-points: before the quarantine, defined as February 2020 (the quarantine started in March 2020 in Sao Paulo), at the baseline interview; and during the quarantine, defined as the two weeks preceding our first follow-up interview.

We reviewed medical records to confirm or collect data on demographic characteristics (age, sex, marital status, education, neighborhood), medical history, cognition [10-point cognitive screener (10-CS)] (33), functional status (Katz index — ADLs) (33), and frailty. Frailty was evaluated using the FRAIL scale, a well-validated screening tool that includes five mnemonic questions on fatigue, resistance, ambulation, illnesses, and loss of weight. FRAIL scores range from 0 to 5, with scores ≥3 classifying older adults as frail (35, 36).

Outcome

Our primary outcome was quality of life, evaluated with the following question: «How is the Coronavirus pandemic affecting your quality of life?». Possible responses were «not at all», «to some extent», and «to a great extent», defining a three-level outcome with the categories «no impact», «minor impact», and «major impact», respectively (37). We used a single measure to capture how people perceive and react to the transformations imposed by the COVID-19 pandemic in their health status and other nonmedical aspects of their lives (38). Quality of life is something that is perceived by each person individually. A single global rating can reflect the different values and preferences of individuals, offering a sensible and easy-to-apply approach to measuring the quality of life, particularly in the context of life transitions or to evaluate the quality of life in specific situations (37, 39). Besides their simplicity, single-item assessments also have the advantage of being better validated for telephone interviews (40).

Statistical analyses

We compared variables according to the three categories of quality of life impact (no impact, minor impact, major impact), using the Kruskal-Wallis test for interval variables and the exact Fisher test for categorical variables.

We used ordinal logistic regression models to investigate which factors were associated with the impact of the COVID-19 quarantine on the quality of life of our population. Our primary independent variable was restricted life-space mobility, defined as a decrease of ≥5 points in LSA scores between measurements (before vs. during the quarantine). We adjusted the regressions for possible confounders, including demographics, comorbidities, cognition, functional status, frailty, loneliness, anxiety, and depression. We tested a preplanned interaction between frailty status and restricted life-space mobility for the impact on the quality of life (41). Variance inflation factors (VIF) did not detect multicollinearity in our models.

Statistical analyses were performed using Stata version 15.1 (Stata Corp. LP, College Station, TX, USA). All statistical tests were two-tailed, and an alpha level <0.05 was accepted to indicate statistical significance.

Results

A total of 886 individuals were pre-screened from our databases as potential candidates for participation. After eligibility assessment, 145 were excluded for circumstances that precluded telephone interviews (mostly severe hearing loss), 104 could not be reached after three contact attempts, 36 refused participation, and 17 were hospitalized when contacted. Finally, 27 were excluded for missing data. Therefore, we included 557 participants from the four study sites for complete-case data analyses (IC=316; InCor=113; HCor=95; ICESP=33). Figure 1 shows the broad distribution of our population in the metropolitan area of Sao Paulo, according to the zip code and study site.

We observed a mean age of 80 years (range 60–100) years, 65% were women, 64% had less than eight years of formal education, and 15% were living alone. Overall, 33% of our participants were frail and, although they were all able to walk, 45% reported gait difficulties, and 26% used assistive devices. Descriptive statistics are presented in Table 1.

Table 1

Characteristics of participants according to the impact of the COVID-19 quarantine on quality of life

	Total Sample	Level of impact of the COVID-19 quarantine on quality of life			P-value
		No impact	Minor impact	Major impact
	(n=SS7)	(n=129)	(n=298)	(n=130)
Age (years), mean (SD)	80 (8)	82(7)	81(8)	78(8)	<0.001
Female, n (%)	360 (65)	80 (62)	202 (68)	78 (60)	0.23
Married, n (%)	238 (43)	49 (38)	128 (43)	61 (47)	0.35
Living alone, n (%)	85(15)	19 (15)	39 (13)	27 (21)	0.13
Middle-school or higher education (≥8 years), n (%)	201 (36)	29 (23)	104 (35)	68 (52)	<0.001
Diabetes, n (%)	186 (33)	44(34)	102 (34)	40(31)	0.77
Heart failure, n (%)	143 (26)	28 (22)	81 (27)	34 (26)	0.50
Cancer, n (%)	95 (17)	19 (15)	58 (20)	18 (14)	0.29
COPD, n (%)	51(9)	9(7)	33 (11.1)	9(7)	0.28
Cognitive performance (10-CS), mean (SD)	8.0(1.3)	7.9(1.3)	8.0(1.4)	8.2(1.3)	0.33
Frailty (FRAIL Scale ≥3), n (%)	183 (33)	29(23)	100 (34)	54 (42)	0.004
ADLs (Katz Index), mean (SD)	5.4(1.1)	5.6 (0.8)	5.4(1.1)	5.4(1.2)	0.21
Reported gait difficulty, n (%)	248 (45)	60 (47)	138 (46)	50 (39)	0.28
Use of mobility assist device, n (%)	147 (26)	29 (23)	84 (28)	34 (2)	0.48
Influenza vaccination, n (%)	419 (75)	100 (78)	224 (75)	95 (73)	0.71
Level of concern about the pandemic, n (%)					<0.001
Not at all	108(19)	55 (43)	48(16)	5(4)
Somewhat	220 (40)	49 (38)	137 (46)	34 (26)
Very much	229 (41)	25 (19)	113 (38)	91(7)
Checking the news about Coronavirus, n (%)					0.08
Never	10 (2)	4(3)	6(2)	0(0)
Sometimes	88 (16)	20 (16)	40(13)	28 (22)
Daily	459 (82)	105 (81)	252 (85)	102 (79)
Regular physical activity (≥3 times per week) before the quarantine, n (%)	235 (42)	41 (32)	126 (42)	68 (52)	0.004
Regular physical activity (≥3 times per week) during the quarantine, n (%)	147 (26)	28 (22)	79 (26)	40 (31)	0.25
LSA before the quarantine, mean (SD)	42 (21)	37 (22)	40 (19)	51 (20)	<0.001
LSA during the quarantine, mean (SD)	21 (12)	24(12)	20 (13)	19(12)	0.009
Loneliness (UCLA-3 ≥ 6), n (%)	70(13)	14(11)	34(11)	22 (17)	0.24
Depression (PHQ-2 ≥ 3), n (%)	54(10)	9(7)	25 (8)	20 (15)	0.05
Anxiety (GAD-2 ≥ 3), n (%)	108 (19)	13 (10)	51 (17)	44(34)	<0.001

LSA = Life-Space Assessment; COPD = Chronic Obstructive Pulmonary Disease; 10-CS = 10-point Cognitive Screener; ADL = Activities of Daily Living; UCLA-3 = 3-item UCLA Loneliness Scale; PHQ-2 = Patient Health Questionnaire 2-item; GAD-2 = Generalized Anxiety Disorder 2-item; SD = standard deviation; Levels of impact on quality of life were compared using the Kruskal-Wallis test for interval variables and the Fisher test for categorical variables.

When questioned about the COVID-19 pandemic, 81% reported being somewhat or very worried, and 82% were checking the news about COVID-19 every day. Compliance with preventive measures against the disease was generally good: 95% were avoiding going out, 87% were practicing social distancing, 80% had increased hand-washing frequency, 75% had been vaccinated against influenza in 2020, and 68% had intensified their environment sanitization routines.

The prevalence of depression (10%) and loneliness (13%) was compatible with what is usually observed in community-dwelling older adults. Conversely, the prevalence of anxiety was higher, affecting 19% of our sample. When asked about the impact of the COVID-19 pandemic on their quality of life, 54% of our participants replied that the pandemic had affected them to some extent, while 23% replied not to have been affected at all, and 23% to have been affected to a great extent. As shown in Table 1, participants who reported a major impact on quality of life were younger, more educated, and had higher levels of anxiety. We did not observe differences in the impact of the COVID-19 quarantine on quality of life according to sex, living arrangement, comorbidities, cognition, physical performance, or frailty.

We verified substantial changes in life-space mobility during the quarantine, in our population. The proportion of participants who reported leaving their homes at least once a week for external activities dropped from 74% before the quarantine to 19% during the quarantine. Furthermore, the proportion of individuals who left their houses every day went from 29% to 2%. Correspondingly, the mean LSA scores dropped from 42 points before the quarantine to 21 points during the quarantine (P<0.001). Most of our patients (79%) decreased their life-space mobility levels in five points or more, fulfilling the criteria for restricted life-space mobility. Physical activity markedly decreased before vs. during the quarantine as well, from 42% to 26% of older adults doing regular physical activity at least three times per week (P<0.001).

We confirmed our hypothesis that the restriction of life-space mobility would be associated with the impact of the COVID-19 quarantine on the quality of life of community-dwelling older adults (Figure 2). In an adjusted regression model, restricted life-space mobility was associated with higher levels of impact on quality of life, with an odds ratio (OR) of 2.18 [95% confidence interval (95% CI) = 1.33–3.58]. Younger age, higher education, and the presence of anxiety were also independently associated with higher levels of impact on quality of life (Table 2).

Figure 2

Life-space assessment scores in community-dwelling older adults, before and during the COVID-19 quarantine (n=557)

Table 2

Factors associated with the impact of the COVID-19 pandemic on the quality of life of community-dwelling older adults (n=557)

	Odds Ratio (95% Confidence Interval)
	Unadjusted Model	Adjusted Model
Restricted life-space mobility (≥ 5-point decrease in LSA)	2.60(1.63–4.17)	2.18 (1.33–3.58)
Frailty (FRAIL Scale ≥ 3)	0.83 (0.39–1.77)	0.72 (0.33–1.61)
Interaction: restricted life-space mobility *frailty	2.43 (1.04–5.69)	2.66 (1.08–6.56)
Age (years)		0.97 (0.95–0.99)
Female sex		1.00 (0.66–1.52)
Middle-school or higher education (≥8 years)		1.93 (1.32–2.83)
Married		1.17 (0.77–1.78)
Living alone		1.33 (0.79–2.23)
Diabetes		0.80 (0.76–1.15)
Heart Failure		1.29 (0.88–1.91)
Cancer		1.16 (0.74–1.81)
COPD		0.94 (0.53–1.66)
Cognitive performance (10-CS score)		1.11 (0.98–1.25)
ADL (Katz Index)		0.91 (0.77–1.08)
Loneliness (UCLA-3 score)		1.13 (0.98–1.30)
Depression (PHQ-2 score)		0.99 (0.84–1.18)
Anxiety (GAD-2 score)		1.43 (1.24–1.64)

LSA = Life-Space Assessment; COPD = Chronic Obstructive Pulmonary Disease; 10-CS = 10-point Cognitive Screener; ADL = Activities of Daily Living; UCLA-3 = 3-item UCLA Loneliness Scale; PHQ-2 = Patient Health Questionnaire 2-item; GAD-2 = Generalized Anxiety Disorder 2-item; Estimates were calculated using ordinal logistic regression model; the dependent variable was the impact on quality of life during the COVID-19 quarantine, categorized in three levels (no impact, minor impact, major impact).

Our preplanned interaction analyses revealed that frailty modified the effect of life-space restriction on the study outcome (P-value for interaction=0.03), indicating that frail older adults had a significantly higher risk of having their quality of life affected by restricted life-space mobility during the pandemic (Table 3).

Table 3

Modification effect of frailty on the association between restricted life-space mobility and the impact of the COVID-19 quarantine on the quality of life of older adults (n=557)

	OR (95% CI) for the impact of the COVID-19 quarantine on quality of life		OR (95% CI) for the impact of restricted life-space mobility on quality of life within each strata of frailty
	Non-restricted life-space mobility	Restricted life-space mobility
Non-frail	1.00 (reference)	2.18(1.33–3.58) P=0.002	2.18(1.33–3.58) P=0.002
Frail	0.72 (0.33–1.61) P=0.43	4.20 (2.36–7.50) P<0.001	5.80 (2.67–12.6) P<0.001

OR = odds ratio; CI = confidence interval; Estimates were calculated using ordinal logistic regression model; the dependent variable was the impact on quality of life during the COVID-19 quarantine, categorized in three levels (no impact, minor impact, major impact). Restricted life-space mobility was defined as a decrease of ≥ 5 points in the Life-Space Assessment. The model was adjusted for age, sex, education, living alone, being married, diabetes, heart failure, cancer, chronic obstructive pulmonary disease, 10-point Cognitive Screener, functionality (Katz index), loneliness, depression, and anxiety; Measure of effect modification on multiplicative scale (2.66; 95% CI = 1.08–6.56; P=0.03).

Discussion

In this multicenter cohort study from the Sao Paulo metropolitan area, we found that four in five community-dwelling older adults experienced a clinically significant reduction in their life-space mobility as a result of the stay-at-home orders during the COVID-19 pandemic. Notably, we verified that restrictions in life-space mobility influenced the impact of the COVID-19 quarantine on older adults’ quality of life, particularly among those who were frail. Understanding how this phenomenon might affect the health and well-being of older people with and without frailty is a crucial step towards the mitigation of some of the negative consequences of the physical distancing measures.

Life-space mobility represented an essential aspect of environmental complexity in older adults (42). Despite not being a direct measure of physical performance, LSA has been described as a comprehensive representation of functioning and a strong predictor of adverse outcomes in older age, including falls, cognitive decline, hospitalization, institutionalization, and death (42–46). While physical performance (such as walking ability) accounts for a significant portion of its final score, LSA is strongly associated with several other factors that influence mobility, including social connections, cognitive performance, personality traits, and mental health (13, 15). All these aspects are crucial for the well-being of older adults.

In this study, we noticed a massive decrease of life-space mobility in a short period of time. The mean LSA score reduced from 42 (before the quarantine) to 21 (during the first weeks of the quarantine), a drop similar to that encountered in older adults who suffered a hip fracture (22). As an example, a decrease from 42 to 21 points would be experienced by an older person who previously reported going out to the neighborhood 4–6 times per week and now can only visit his/her own yard or porch with the same frequency.

We also found that frail older adults had higher odds of having their quality of life affected by restrictions in life-space mobility. Previous studies have demonstrated that frail older adults have lower levels of perceived autonomy (47). Therefore, it is possible that in a scenario where social distancing recommendations further limited their already constricted autonomy, frail individuals felt more impacted by the COVID-19 quarantine (21). Another vital concern raised by our results was the considerable decrease in regular physical activity. Frailty, sarcopenia, and chronic diseases are just some of the many health problems that can be aggravated by physical inactivity in older people (48). Although the long-term consequences of these abrupt lifestyle changes are still unclear, they are likely to be particularly harmful for the geriatric population (24).

Modern healthcare systems had never been required to adapt to such rigorous and widespread quarantine orders. It quickly became evident that resources such as telemedicine and home-based exercise programs would be critical for maintaining the health of vulnerable populations (49). For instance, our telephone interviews also represent a simple, low-cost, and reproducible strategy to maintain essential aspects of follow-up during the quarantine. They can also be employed to educate patients regarding the COVID-19 pandemic, provide basic health care recommendations, and identify patients requiring additional psychological support (49).

Our work had important strengths. It was a multicenter study conducted in the epicenter of the COVID-19 pandemic in Brazil. Besides, we completed our interviews during the outbreak in Sao Paulo, which allowed us to investigate the real-time consequences of the unexpected scenario. Finally, we were able to adjust our analyses for several possible confounders of the association between life-space mobility and quality of life.

Even so, the study had some limitations. We excluded patients with dementia, limiting the external generalizability of the results. Given that frailty is often associated with other geriatric syndromes, future studies should explore our findings in individuals with cognitive impairment or hearing loss. Also, we asked our patients about their physical activity and life-space mobility levels before the pandemic, and their answers could have been subject to recall bias. Another possible limitation was our use of a single question to evaluate quality of life during the COVID-19 quarantine. Still, our choices are justified by existing evidence that demonstrates high levels of validity of single-item assessments to capture changes in quality of life associated with specific contexts (50, 51). Instead of improving measurements, a multi-domain assessment could confound the dimensionality of outcome with multiple causal sources (39).

In conclusion, we observed substantial decreases in life-space mobility during the COVID-19 quarantine, and we verified that restrictions on life-space were associated with the impact of the quarantine on the quality of life of community-dwelling older adults. Providers should be aware that frail individuals were particularly vulnerable to the effects of restricted life-space mobility on quality of life and explore strategies to minimize their suffering during the COVID-19 pandemic. We plan to follow our cohort during the next months to advance our understanding of trajectories of physical and mental health in geriatric patients after the COVID-19 quarantine.

The impact of frailty on the relationship between life-space mobility and quality of life in older adults during the COVID-19 pandemic