Aakansha Zala1, Louise J Maple-Brown2, Jonathan E Shaw3, Matthew JL Hare4. 1. MBBS, FRACP, Endocrinologist, Department of Endocrinology, Princess Alexandra Hospital, Woolloongabba, Qld; Endocrinology Research Fellow, The University of Queensland Diamantina Institute, Translational Research Institute, Qld. 2. MBBS, FRACP, PhD, Head, Department of Endocrinology, Royal Darwin Hospital, NT; Head, Diabetes across the Lifecourse: Northern Australia Partnership, Menzies School of Health Research, Charles Darwin University, NT. 3. MD, FRACP, FRCP(UK), FAAHMS, Deputy Director (Clinical and Population Health), Baker Heart and Diabetes Institute, Vic; Professor, School of Public Health and Preventive Medicine, Monash University, Vic. 4. MBBS, BMedSc, FRACP, Endocrinologist, Department of Endocrinology, Royal Darwin Hospital, NT; Menzies School of Health Research, Charles Darwin University, NT.
Abstract
BACKGROUND: The burden of type 2 diabetes (T2D) and its associated complications continues to grow in Australia. In recent years, sodium-glucose co-transporter-2 (SGLT2) inhibitors have become a key component of diabetes care with rapid uptake into routine clinical practice. There is growing evidence of their clinical efficacy, but also potential adverse effects. OBJECTIVE: The aim of this article is to review the use of SGLT2 inhibitors in T2D by exploring data surrounding clinical efficacy and safety as well as providing practical advice for prescribing clinicians. DISCUSSION: SGLT2 inhibitors have multiple metabolic benefits including reducing glycated haemoglobin, weight and blood pressure. Additionally, there are strong cardiovascular benefits and renoprotective effects in selected populations. Current evidence suggests that SGLT2 inhibitors should be considered for the secondary prevention of cardiovascular disease and to delay progression of early chronic kidney disease in people with T2D. Clinicians should also be aware of common side effects and potential rare severe complications.
BACKGROUND: The burden of type 2 diabetes (T2D) and its associated complications continues to grow in Australia. In recent years, sodium-glucose co-transporter-2 (SGLT2) inhibitors have become a key component of diabetes care with rapid uptake into routine clinical practice. There is growing evidence of their clinical efficacy, but also potential adverse effects. OBJECTIVE: The aim of this article is to review the use of SGLT2 inhibitors in T2D by exploring data surrounding clinical efficacy and safety as well as providing practical advice for prescribing clinicians. DISCUSSION: SGLT2 inhibitors have multiple metabolic benefits including reducing glycated haemoglobin, weight and blood pressure. Additionally, there are strong cardiovascular benefits and renoprotective effects in selected populations. Current evidence suggests that SGLT2 inhibitors should be considered for the secondary prevention of cardiovascular disease and to delay progression of early chronic kidney disease in people with T2D. Clinicians should also be aware of common side effects and potential rare severe complications.
Authors: Marc Evans; Angharad R Morgan; Stephen C Bain; Sarah Davies; Umesh Dashora; Smeeta Sinha; Samuel Seidu; Dipesh C Patel; Hannah Beba; W David Strain Journal: Diabetes Ther Date: 2022-03-29 Impact factor: 3.595