Literature DB >> 3378575

Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release.

D J Dooley1, A Lupp, G Hertting, H Osswald.   

Abstract

The tritium overflow evoked by electrical stimulation of rabbit hippocampal slices labeled with [3H]noradrenaline was inhibited by omega-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel (N-VSCC). The magnitude of this inhibition was unchanged in the presence of substances which interact with N- and/or L-VSCCs (cadmium, neomycin, (-)- and (+)-202-791), alpha 2-adrenoceptors (idazoxan, UK-14304), protein kinase C (4 beta-phorbol-12,13-dibutyrate) or potassium channels (4-aminopyridine). This finding suggests that the attenuation of calcium-dependent neurotransmitter release by omega-conotoxin GVIA is relatively insensitive to alterations of such release effected by other substances.

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Year:  1988        PMID： 3378575     DOI： 10.1016/0014-2999(88)90572-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Role of neuronal and vascular Ca(2+)-channels in the ACTH-induced reversal of haemorrhagic shock.

Authors:  S Guarini; C Bazzani; A Bertolini
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

2.  N- and P-type Ca2+ channels are involved in acetylcholine release at a neuroneuronal synapse: only the N-type channel is the target of neuromodulators.

Authors:  P Fossier; G Baux; L Tauc
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

3.  Release of secretoneurin and noradrenaline from hypothalamic slices and its differential inhibition by calcium channel blockers.

Authors:  J Troger; R Kirchmair; J Marksteiner; C V Seidl; R Fischer-Colbrie; A Saria; H Winkler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-06       Impact factor: 3.000

4.  Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

Authors:  M Ino; T Yoshinaga; M Wakamori; N Miyamoto; E Takahashi; J Sonoda; T Kagaya; T Oki; T Nagasu; Y Nishizawa; I Tanaka; K Imoto; S Aizawa; S Koch; A Schwartz; T Niidome; K Sawada; Y Mori
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

5.  Characterization of the role of calcium and sodium channels in the stimulus secretion coupling of 5-hydroxytryptamine release from porcine enterochromaffin cells.

Authors:  K Racké; H Schwörer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

6.  Differential effects of calcium channel antagonists (omega-conotoxin GVIA, nifedipine, verapamil) on the electrically-evoked release of [3H]acetylcholine from the myenteric plexus, phrenic nerve and neocortex of rats.

Authors:  I Wessler; D J Dooley; J Werhand; F Schlemmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

7.  The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.

Authors:  A L Horne; J A Kemp
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

8.  Actions of neomycin on neuronal L-, N-, and non-L/non-N-type voltage-sensitive calcium channel responses.

Authors:  R A Keith; T J Mangano; P A DeFeo; M B Horn; A I Salama
Journal:  J Mol Neurosci       Date:  1992       Impact factor: 3.444

9.  Inhibition of noradrenaline release by omega-conotoxin GVIA in the rat tail artery.

Authors:  B Clasbrummel; H Osswald; P Illes
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

10.  Multiple Ca2+ channel types coexist to regulate synaptosomal neurotransmitter release.

Authors:  T J Turner; M E Adams; K Dunlap
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205
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