Literature DB >> 33783741

Pathway Engineering Using Escherichia coli to Produce Commercialized Carotenoids.

Hisashi Harada1.   

Abstract

The biosynthesis of commercialized carotenoids (e.g., lycopene, β-carotene, zeaxanthin, and astaxanthin) using recombinant microorganisms is one of the reasonable and cost-effective alternatives to extraction from natural sources and chemical synthesis. Among heterologous hosts, Escherichia coli is one of the most useful and manageable. To date, many approaches using recombinant E. coli are available to produce various carotenoids. Here we outline the latest carotenoid production research using recombinant E. coli produced through pathway engineering and its future prospects.

Entities:  

Keywords:  Commercialized carotenoids; Escherichia coli; Mevalonate pathway; Pathway engineering

Mesh:

Substances:

Year:  2021        PMID: 33783741     DOI: 10.1007/978-981-15-7360-6_16

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  22 in total

1.  Tuning genetic control through promoter engineering.

Authors:  Hal Alper; Curt Fischer; Elke Nevoigt; Gregory Stephanopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-25       Impact factor: 11.205

2.  Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

Authors:  Hal Alper; Yong-Su Jin; J F Moxley; G Stephanopoulos
Journal:  Metab Eng       Date:  2005-05       Impact factor: 9.783

3.  Transporter-mediated biofuel secretion.

Authors:  Rupak Doshi; Tuan Nguyen; Geoffrey Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-23       Impact factor: 11.205

4.  Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli.

Authors:  S Kajiwara; P D Fraser; K Kondo; N Misawa
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

5.  Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets.

Authors:  Hal Alper; Kohei Miyaoku; Gregory Stephanopoulos
Journal:  Nat Biotechnol       Date:  2005-04-10       Impact factor: 54.908

6.  Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

Authors:  N Campos; M Rodríguez-Concepción; S Sauret-Güeto; F Gallego; L M Lois; A Boronat
Journal:  Biochem J       Date:  2001-01-01       Impact factor: 3.857

7.  Uncovering the gene knockout landscape for improved lycopene production in E. coli.

Authors:  Hal Alper; Gregory Stephanopoulos
Journal:  Appl Microbiol Biotechnol       Date:  2008-02-01       Impact factor: 4.813

8.  Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli.

Authors:  Hisashi Harada; Fengnian Yu; Sho Okamoto; Tomohisa Kuzuyama; Ryutaro Utsumi; Norihiko Misawa
Journal:  Appl Microbiol Biotechnol       Date:  2008-10-03       Impact factor: 4.813

9.  Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli.

Authors:  Yong-Su Jin; Gregory Stephanopoulos
Journal:  Metab Eng       Date:  2007-04-12       Impact factor: 9.783

10.  A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes.

Authors:  Maiko Furubayashi; Mayu Ikezumi; Shinichi Takaichi; Takashi Maoka; Hisashi Hemmi; Takuya Ogawa; Kyoichi Saito; Alexander V Tobias; Daisuke Umeno
Journal:  Nat Commun       Date:  2015-07-14       Impact factor: 14.919

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