| Literature DB >> 33782814 |
You Lv1, Kun Li1, Wei Gao1, Zesheng Hao1, Weibo Wang1, Xiaoyu Liu1, Liangfu Tang2, Zhijin Fan3.
Abstract
Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins were rationally designed and synthesized. Preliminary bioassay showed that compounds 7c, 7h and 7l exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50 μg/mL, 7c exhibited good activity against S. sclerotiorum with median effective concentration (EC50) of 4.08 μg/mL, while the positive control coumoxystrobin showed EC50 of 1.00 μg/mL. In addition, 7d showed better fungicidal activity with a lower EC50 value of 7.65 μg/mL against Botrytis cinerea than that of positive control trifloxystrobin with its EC50 value of 21.96 μg/mL. This study indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurin was a promising fungicide lead deserved for further study.Entities:
Keywords: Antifungal activity; Coumarin; Molecular design; Strobilurin; Synthesis
Mesh：
Substances：
Year: 2021 PMID： 33782814 DOI： 10.1007/s11030-021-10207-5
Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943