A Novel Organic Composite Accelerates Wound Healing: Experimental and Clinical Study in Equine.

Natural products such as honey, rosemary and chamomile oils have many health benefits particularly skin regeneration. These products were previously examined individually as enhancer of skin wound healing. The purpose of this study was to evaluate the clinical and histopathological features associated with using a mixture of rosemary and chamomile oils with honey, as a composite, in healing of equine-skin wounds experimentally and clinically. For experimental and clinical evaluation 15 donkeys and 122 clinical cases were used, respectively. For the experimental part, animals were divided into five equal groups. In each animal one skin wound was created bilaterally on the back region. All left-side wounds were treated with saline. Right-side wounds were treated with one of the following treatments, gentamycin, zinc, Kruuse Manuka, Revan and the composite ointments. Each wound treated once daily until one of the wounds healed completely. wounds were evaluated grossly and histopathologically. In clinical cases, wounds were dressed with the composite once daily and monitored until healing. Experimentally induced wounds treated with the composite were healed firstly, while all other wounds were still opened. Histologically, the skin of the composite treated wounds regenerated completely and efficiently. While the skin of the other wounds, showing incomplete regeneration of epidermis and dermis. Under field condition, the composite accelerates healing of different forms of equine wounds. The tested composite induce efficient and rapid skin regeneration.