Literature DB >> 33780745

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD.

Wenhao Jiang1, Kelly Rootes-Murdy2, Kuaikuai Duan3, Gido Schoenmacker4, Pieter J Hoekstra5, Catharina A Hartman5, Jaap Oosterlaan6, Dirk Heslenfeld7, Barbara Franke4, Emma Sprooten8, Jan Buitelaar9, Alejandro Arias-Vasquez4, Jingyu Liu10, Jessica A Turner11.   

Abstract

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.
Copyright © 2021. Published by Elsevier B.V.

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Mesh：

Year:  2021        PMID： 33780745      PMCID： PMC8058322          DOI： 10.1016/j.pscychresns.2021.111282

Source DB:  PubMed          Journal:  Psychiatry Res Neuroimaging        ISSN： 0925-4927            Impact factor:   2.493


  32 in total

Review 1.  Molecular genetics of attention-deficit/hyperactivity disorder.

Authors:  Stephen V Faraone; Roy H Perlis; Alysa E Doyle; Jordan W Smoller; Jennifer J Goralnick; Meredith A Holmgren; Pamela Sklar
Journal:  Biol Psychiatry       Date:  2005-01-21       Impact factor: 13.382

2.  PRSice-2: Polygenic Risk Score software for biobank-scale data.

Authors:  Shing Wan Choi; Paul F O'Reilly
Journal:  Gigascience       Date:  2019-07-01       Impact factor: 6.524

3.  The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis.

Authors:  Steven G Dickstein; Katie Bannon; F Xavier Castellanos; Michael P Milham
Journal:  J Child Psychol Psychiatry       Date:  2006-10       Impact factor: 8.982

4.  The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives.

Authors:  Daniel von Rhein; Maarten Mennes; Hanneke van Ewijk; Annabeth P Groenman; Marcel P Zwiers; Jaap Oosterlaan; Dirk Heslenfeld; Barbara Franke; Pieter J Hoekstra; Stephen V Faraone; Catharina Hartman; Jan Buitelaar
Journal:  Eur Child Adolesc Psychiatry       Date:  2014-07-11       Impact factor: 4.785

Review 5.  Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology.

Authors:  Thomas J Spencer; Joseph Biederman; Eric Mick
Journal:  J Pediatr Psychol       Date:  2007-06-07

6.  Quantifying patterns of brain activity: Distinguishing unaffected siblings from participants with ADHD and healthy individuals.

Authors:  Thomas Wolfers; Daan van Rooij; Jaap Oosterlaan; Dirk Heslenfeld; Catharina A Hartman; Pieter J Hoekstra; Christian F Beckmann; Barbara Franke; Jan K Buitelaar; Andre F Marquand
Journal:  Neuroimage Clin       Date:  2016-07-02       Impact factor: 4.881

7.  Risk factors for comorbid oppositional defiant disorder in attention-deficit/hyperactivity disorder.

Authors:  Siri D S Noordermeer; Marjolein Luman; Wouter D Weeda; Jan K Buitelaar; Jennifer S Richards; Catharina A Hartman; Pieter J Hoekstra; Barbara Franke; Dirk J Heslenfeld; Jaap Oosterlaan
Journal:  Eur Child Adolesc Psychiatry       Date:  2017-03-10       Impact factor: 4.785

8.  Shared genetic background between children and adults with attention deficit/hyperactivity disorder.

Authors:  Paula Rovira; Ditte Demontis; Anders D Børglum; Barbara Franke; Josep Antoni Ramos-Quiroga; María Soler Artigas; Marta Ribasés; Cristina Sánchez-Mora; Tetyana Zayats; Marieke Klein; Nina Roth Mota; Heike Weber; Iris Garcia-Martínez; Mireia Pagerols; Laura Vilar-Ribó; Lorena Arribas; Vanesa Richarte; Montserrat Corrales; Christian Fadeuilhe; Rosa Bosch; Gemma Español Martin; Peter Almos; Alysa E Doyle; Eugenio Horacio Grevet; Oliver Grimm; Anne Halmøy; Martine Hoogman; Mara Hutz; Christian P Jacob; Sarah Kittel-Schneider; Per M Knappskog; Astri J Lundervold; Olga Rivero; Diego Luiz Rovaris; Angelica Salatino-Oliveira; Bruna Santos da Silva; Evgeniy Svirin; Emma Sprooten; Tatyana Strekalova; Alejandro Arias-Vasquez; Edmund J S Sonuga-Barke; Philip Asherson; Claiton Henrique Dotto Bau; Jan K Buitelaar; Bru Cormand; Stephen V Faraone; Jan Haavik; Stefan E Johansson; Jonna Kuntsi; Henrik Larsson; Klaus-Peter Lesch; Andreas Reif; Luis Augusto Rohde; Miquel Casas
Journal:  Neuropsychopharmacology       Date:  2020-04-12       Impact factor: 7.853

9.  Evaluation of the Persistence, Remission, and Emergence of Attention-Deficit/Hyperactivity Disorder in Young Adulthood.

Authors:  Jessica C Agnew-Blais; Guilherme V Polanczyk; Andrea Danese; Jasmin Wertz; Terrie E Moffitt; Louise Arseneault
Journal:  JAMA Psychiatry       Date:  2016-07-01       Impact factor: 21.596

10.  The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology.

Authors:  Isabell Brikell; Henrik Larsson; Yi Lu; Erik Pettersson; Qi Chen; Ralf Kuja-Halkola; Robert Karlsson; Benjamin B Lahey; Paul Lichtenstein; Joanna Martin
Journal:  Mol Psychiatry       Date:  2018-06-22       Impact factor: 15.992
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