Extracellular Vesicles in Neurological Disorders.

The role of extracellular vesicles (EVs) in the central nervous system, and in particular the brain, is a rapidly growing research area. Importantly, the role for EVs in the nervous system spans from early development through to old age, with EVs being associated with several different neurological disorders. To date, researchers have been studying the function of EVs in the nervous system in three major areas: (i) the role of EVs in promoting disease pathways, (ii) the ability of EVs to be used as a diagnostic tool to identify cellular changes in the nervous system, and (iii) the potential use of EVs as therapeutic tools for the delivery of biomolecules or drugs to the nervous system. In each of these settings the analysis and use of EVs performs a different function, highlighting the breadth of areas in which the EV field is applicable. A key aspect of EV biology is the ability of vesicles to cross biological barriers, in particular the blood brain barrier. This allows for the measurement of serum EVs that contain information about cells in the brain, or alternatively, allows for the delivery of biomolecules that are packaged within EVs for therapeutic use.