S Grace Prakalapakorn1,2, Nikhil Sarin3, Neeru Sarin3, Brendan McGeehan4, Du Tran-Viet3, Vincent Tai3, Gui-Shuang Ying5, Cynthia A Toth3, Sharon F Freedman3,6. 1. Department of Ophthalmology, Duke University, 2351 Erwin Rd, DUMC 3802, Durham, 27710, NC, USA. grace.prakalapakorn@duke.edu. 2. Department of Pediatrics, Duke University, Durham, NC, USA. grace.prakalapakorn@duke.edu. 3. Department of Ophthalmology, Duke University, 2351 Erwin Rd, DUMC 3802, Durham, 27710, NC, USA. 4. Center for Preventative Ophthalmology and Biostatistics, Philadelphia, PA, USA. 5. Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. 6. Department of Pediatrics, Duke University, Durham, NC, USA.
Abstract
PURPOSE: To study the association of clinical factors and optical coherence tomography (OCT) retinal imaging with axial length (AL) and AL growth in preterm infants METHODS: Among a subgroup of infants from the prospective BabySTEPS study who were screened for retinopathy of prematurity (ROP) and had both AL measured and OCT imaging performed, we analyzed data collected prior to 42 weeks postmenstrual age (PMA) and prior to ROP treatment. Using linear mixed effects models, we evaluated associations between AL and AL growth with gestational age (GA), birthweight, PMA, sex, race, multiparity, maximum ROP stage, and OCT features. RESULTS: We included 66 infants (132 eyes), mean GA = 27.6 weeks (SD = 2.3; range: 23.0-34.4) and mean birthweight = 961 g (SD = 269, range: 490-1580). In the final predictive model, longer AL was associated with earlier GA, higher birthweight, later PMA, non-White race, and thicker subfoveal choroid (all p values ≤ 0.01). AL increased linearly up to 42 weeks PMA. There was no difference in AL growth rate by GA, sex, race, multiparity, maximum ROP severity, central foveal thickness, or subfoveal choroidal thickness (all p values > 0.05); but AL growth rate was slower in infants with lower birthweight (p = 0.01). CONCLUSIONS: Among preterm infants, those with earlier GA, higher birthweight, later PMA, non-White race, and thicker subfoveal choroid had the longest AL. AL increased linearly up to 42 weeks PMA and lower birthweight was associated with slower AL growth. These findings may improve the accuracy of measurements taken on preterm infants using imaging techniques affected by AL (e.g., measuring lateral dimensions on OCT). TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT02887157 , date of registration: August 25, 2016.
PURPOSE: To study the association of clinical factors and optical coherence tomography (OCT) retinal imaging with axial length (AL) and AL growth in preterm infants METHODS: Among a subgroup of infants from the prospective BabySTEPS study who were screened for retinopathy of prematurity (ROP) and had both AL measured and OCT imaging performed, we analyzed data collected prior to 42 weeks postmenstrual age (PMA) and prior to ROP treatment. Using linear mixed effects models, we evaluated associations between AL and AL growth with gestational age (GA), birthweight, PMA, sex, race, multiparity, maximum ROP stage, and OCT features. RESULTS: We included 66 infants (132 eyes), mean GA = 27.6 weeks (SD = 2.3; range: 23.0-34.4) and mean birthweight = 961 g (SD = 269, range: 490-1580). In the final predictive model, longer AL was associated with earlier GA, higher birthweight, later PMA, non-White race, and thicker subfoveal choroid (all p values ≤ 0.01). AL increased linearly up to 42 weeks PMA. There was no difference in AL growth rate by GA, sex, race, multiparity, maximum ROP severity, central foveal thickness, or subfoveal choroidal thickness (all p values > 0.05); but AL growth rate was slower in infants with lower birthweight (p = 0.01). CONCLUSIONS: Among preterm infants, those with earlier GA, higher birthweight, later PMA, non-White race, and thicker subfoveal choroid had the longest AL. AL increased linearly up to 42 weeks PMA and lower birthweight was associated with slower AL growth. These findings may improve the accuracy of measurements taken on preterm infants using imaging techniques affected by AL (e.g., measuring lateral dimensions on OCT). TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT02887157 , date of registration: August 25, 2016.
Authors: Rachel Linderman; Alexander E Salmon; Margaret Strampe; Madia Russillo; Jamil Khan; Joseph Carroll Journal: Transl Vis Sci Technol Date: 2017-06-09 Impact factor: 3.283
Authors: Shwetha Mangalesh; Brendan McGeehan; Vincent Tai; Xi Chen; Du Tran-Viet; Lejla Vajzovic; Christian Viehland; Joseph A Izatt; C Michael Cotten; Sharon F Freedman; Maureen G Maguire; Cynthia A Toth Journal: Ophthalmol Retina Date: 2020-09-11
Authors: Rachel E Linderman; Elizabeth Heffernan; Samantha Ferrante; Jane Bachman Groth; Joseph Carroll Journal: Optom Vis Sci Date: 2022-02-01 Impact factor: 1.973