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Literature DB >> 3377964

An experimental model of post-traumatic osteomyelitis in rabbits.

P Worlock¹, R Slack, L Harvey, R Mawhinney.

Abstract

An experimental model of a contaminated open fracture, using the tibia of male New Zealand white rabbits, is described. Post-traumatic osteomyelitis can be reliably induced in this model, with no systemic ill-effects. The characteristic bacteriological, radiological and histological findings are described. Inoculation of the fracture site with Staphylococcus aureus in a concentration of 10(6) bacteria caused osteomyelitis in two out of five rabbits. When the concentration of inoculum was increased to 10(7) organisms, osteomyelitis was seen in four out of five rabbits. No cases of infection were seen in the control animals. This is a simple and reliable model for studies into the prevention and treatment of post-traumatic osteomyelitis.

Entities: Disease Species

Mesh：

Year: 1988 PMID： 3377964 PMCID： PMC2013214

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

7 in total

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Journal: J Orthop Res Date: 2008-01 Impact factor: 3.494

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Authors: Gabriele Meroni; Alexios Tsikopoulos; Konstantinos Tsikopoulos; Francesca Allemanno; Piera Anna Martino; Joel Fernando Soares Filipe
Journal: Microorganisms Date: 2022-05-31

3. Acute infections after fracture repair: management with hardware in place.

Authors: Eric Rightmire; David Zurakowski; Mark Vrahas
Journal: Clin Orthop Relat Res Date: 2008-01-10 Impact factor: 4.176

Review 4. A systematic review of animal models for Staphylococcus aureus osteomyelitis.

Authors: W Reizner; J G Hunter; N T O'Malley; R D Southgate; E M Schwarz; S L Kates
Journal: Eur Cell Mater Date: 2014-03-25 Impact factor: 3.942

5. A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model.

Authors: Benjamin D Brooks; Kristofer D Sinclair; David W Grainger; Amanda E Brooks
Journal: PLoS One Date: 2015-03-27 Impact factor: 3.240