Yangheng Zhang1, Dan Qiao1, Rixin Chen1, Feng Zhu2, Jianfeng Gong2, Fuhua Yan1. 1. Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China. 2. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Abstract
BACKGROUND: It has been reported that patients with inflammatory bowel disease (IBD) are more susceptible to periodontitis. However, data regarding the risk of periodontitis in IBD patients are scarce, and results from individual studies remain controversial. The aim of this study is to investigate the risk of periodontitis in IBD patients. METHODS: Web of Science, PubMed, and Embase were searched for studies investigating the risk of periodontitis in the IBD patient population from Jan. 2000 to Nov. 2020. Articles were included if they contained the number of people with IBD diagnosed with periodontitis (or periodontal disease parameters) compared with a control group. Case reports, reviews, animal studies, and articles without available abstracts were excluded. A pooled odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association between periodontitis and IBD. RESULTS: Six studies were included in the meta-analysis. The overall risk of periodontitis was significantly higher in IBD patients than controls (OR: 2.10, 95% CI: 1.60-2.74; I 2 = 27%). In particular, Crohn's disease (CD) and ulcerative colitis (UC) were both linked to an increased risk of periodontitis (OR: 1.72, 95% CI: 1.36-2.19; I 2 = 0% for CD vs. OR:2.39, 95% CI: 1.19-4.80; I 2 = 85% for UC). CONCLUSIONS: IBD patients are at higher risk of periodontitis than controls. After subgroup analysis, the elevated risk remained significant when analyzing CD or UC alone. UC patients were at higher risk of developing periodontitis than CD patients.
BACKGROUND: It has been reported that patients with inflammatory bowel disease (IBD) are more susceptible to periodontitis. However, data regarding the risk of periodontitis in IBD patients are scarce, and results from individual studies remain controversial. The aim of this study is to investigate the risk of periodontitis in IBD patients. METHODS: Web of Science, PubMed, and Embase were searched for studies investigating the risk of periodontitis in the IBD patient population from Jan. 2000 to Nov. 2020. Articles were included if they contained the number of people with IBD diagnosed with periodontitis (or periodontal disease parameters) compared with a control group. Case reports, reviews, animal studies, and articles without available abstracts were excluded. A pooled odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association between periodontitis and IBD. RESULTS: Six studies were included in the meta-analysis. The overall risk of periodontitis was significantly higher in IBD patients than controls (OR: 2.10, 95% CI: 1.60-2.74; I 2 = 27%). In particular, Crohn's disease (CD) and ulcerative colitis (UC) were both linked to an increased risk of periodontitis (OR: 1.72, 95% CI: 1.36-2.19; I 2 = 0% for CD vs. OR:2.39, 95% CI: 1.19-4.80; I 2 = 85% for UC). CONCLUSIONS: IBD patients are at higher risk of periodontitis than controls. After subgroup analysis, the elevated risk remained significant when analyzing CD or UC alone. UC patients were at higher risk of developing periodontitis than CD patients.
Authors: Jamal M Stein; Frank Lammert; Vincent Zimmer; Marie Granzow; Stefan Reichert; Susanne Schulz; Christina Ocklenburg; Georg Conrads Journal: J Periodontol Date: 2010-04 Impact factor: 6.993
Authors: Thomas Greuter; Fabio Bertoldo; Roman Rechner; Alex Straumann; Luc Biedermann; Jonas Zeitz; Benjamin Misselwitz; Michael Scharl; Gerhard Rogler; Ekaterina Safroneeva; Raja A R Ali; Christian Braegger; Klaas Heyland; Pascal Mueller; Andreas Nydegger; Laetitia-Marie Petit; Susanne Schibli; Raoul I Furlano; Johannes Spalinger; Michela Schäppi; Samuel Zamora; Florian Froehlich; Denise Herzog; Alain M Schoepfer; Stephan R Vavricka Journal: J Pediatr Gastroenterol Nutr Date: 2017-08 Impact factor: 2.839
Authors: Mohamed Attauabi; Gorm Roager Madsen; Flemming Bendtsen; Anne Vibeke Wewer; Rune Wilkens; Johan Ilvemark; Nora Vladimirova; Annette Bøjer Jensen; Frank Krieger Jensen; Sanja Bay Hansen; Hartwig Roman Siebner; Yousef Jesper Wirenfeldt Nielsen; Jakob M Møller; Henrik S Thomsen; Simon Francis Thomsen; Helene Andrea Sinclair Ingels; Klaus Theede; Trine Boysen; Jacob T Bjerrum; Christian Jakobsen; Maria Dorn-Rasmussen; Sabine Jansson; Yiqiu Yao; Ewa Anna Burian; Frederik Trier Møller; Viktoria Fana; Charlotte Wiell; Lene Terslev; Mikkel Østergaard; Kristina Bertl; Andreas Stavropoulos; Jakob B Seidelin; Johan Burisch Journal: BMJ Open Date: 2022-06-27 Impact factor: 3.006