BACKGROUND: Flow diversion (FD) has become a widely adopted treatment method for intracranial aneurysms in the clinic, but a comprehensive meta-analysis of large-sample studies including anterior and posterior circulation is still lacking. METHODS: The PubMed, Embase, Web of Science, and Cochrane databases were searched between January 1, 2008, and December 1, 2019. A random-effect model was used to calculate the efficacy and safety data as well as 95% confidence intervals (CIs). RESULTS: The pooled sample size of all included studies was 6695 patients; the mean age was 55.5 years old, with a total of 7406 aneurysms. For efficacy, the complete occlusion rate in angiographic follow-up (AFU) at 6 months was 78% (95% CI, 0.77, 0.80), and the AFU rate at 6-12 months was 90% (95% CI, 0.88, 0.92). For safety, the hemorrhagic event rate was 2%, the ischemic event rate was 5%, and the mortality rate was 3%. CONCLUSION: FD is an effective and safe treatment for intracranial aneurysm with high complete occlusion rate and acceptable complication rate.
BACKGROUND: Flow diversion (FD) has become a widely adopted treatment method for intracranial aneurysms in the clinic, but a comprehensive meta-analysis of large-sample studies including anterior and posterior circulation is still lacking. METHODS: The PubMed, Embase, Web of Science, and Cochrane databases were searched between January 1, 2008, and December 1, 2019. A random-effect model was used to calculate the efficacy and safety data as well as 95% confidence intervals (CIs). RESULTS: The pooled sample size of all included studies was 6695 patients; the mean age was 55.5 years old, with a total of 7406 aneurysms. For efficacy, the complete occlusion rate in angiographic follow-up (AFU) at 6 months was 78% (95% CI, 0.77, 0.80), and the AFU rate at 6-12 months was 90% (95% CI, 0.88, 0.92). For safety, the hemorrhagic event rate was 2%, the ischemic event rate was 5%, and the mortality rate was 3%. CONCLUSION: FD is an effective and safe treatment for intracranial aneurysm with high complete occlusion rate and acceptable complication rate.
Authors: Tibor Becske; David F Kallmes; Isil Saatci; Cameron G McDougall; István Szikora; Giuseppe Lanzino; Christopher J Moran; Henry H Woo; Demetrius K Lopes; Aaron L Berez; Daniel J Cher; Adnan H Siddiqui; Elad I Levy; Felipe C Albuquerque; David J Fiorella; Zsolt Berentei; Miklós Marosfoi; Saruhan H Cekirge; Peter K Nelson Journal: Radiology Date: 2013-02-15 Impact factor: 11.105
Authors: G Foa Torres; F Roca; A Noguera; J Godes; S Petrocelli; I Aznar; S Ales; P Muszynski; R Maehara; M Vicente; J M Pumar Journal: Interv Neuroradiol Date: 2018-05-02 Impact factor: 1.610
Authors: George S Sfyroeras; Ilias Dalainas; Triantafyllos G Giannakopoulos; Konstantinos Antonopoulos; John D Kakisis; Christos D Liapis Journal: J Vasc Surg Date: 2012-07-26 Impact factor: 4.268
Authors: Omer F Eker; Boris Lubicz; Melissa Cortese; Cedric Delporte; Moncef Berhouma; Bastien Chopard; Vincent Costalat; Alain Bonafé; Catherine Alix-Panabières; Pierre Van Anwterpen; Karim Zouaoui Boudjeltia Journal: Front Cardiovasc Med Date: 2022-09-14