BACKGROUND/AIMS: Hashimoto thyroiditis, characterized by positive thyroid peroxidase antibodies (TPOAbs), is caused by the interaction of genetic and environment factors. The aim of this study was to clarify the interaction of gene polymorphisms and iodine intake in the incidence of TPOAb positivity. METHODS: 1,733 subjects were included in this study. Genomic DNA was extracted from peripheral blood white cells. Four SNPs (rs11675434 [TPO], rs3094228 [HCP5], rs9277555 [HLA-DPB1], and rs301799 [RERE]) were selected for genotyping. Weighted TPOAb genetic risk score (GRS) was calculated based on these 4 SNPs. Thyroid hormones and autoimmune antibodies (TPOAb and thyroglobulin antibody) were determined using the electrochemiluminescence immunoassay method. RESULTS: The mean serum thyrotropin level in TPOAb-positive subjects was higher than in TPOAb-negative subjects (p < 0.01). Genotype GG of rs9277555 was associated with an increased risk of TPOAb positivity (OR = 1.64, 5-95% CI 1.09, 2.47, p = 0.02). Genotype TT of rs11675434 showed marginal increased risk of TPOAb positivity (OR = 1.57, 5-95% CI 1.01, 2.43, p = 0.048). Logistic regression analysis showed TPOAb-GRS and rs9277555 were associated with TPOAb positivity (OR = 5.09, 5-95% CI 1.30, 19.91, p = 0.02 and OR = 1.30, 5-95% CI 1.05, 1.61, p = 0.02). Subjects with a high TPOAb-GRS had a 52% increased risk of TPOAb positivity compared to subjects with a low TPOAb-GRS (OR 1.52, 5-95% CI 1.05, 2.21, p = 0.03). CONCLUSION: TPOAb-GRS was associated with an increased risk of TPOAb positivity in a Chinese Han population. This effect might be attribute to rs9277555.
BACKGROUND/AIMS: Hashimoto thyroiditis, characterized by positive thyroid peroxidase antibodies (TPOAbs), is caused by the interaction of genetic and environment factors. The aim of this study was to clarify the interaction of gene polymorphisms and iodine intake in the incidence of TPOAb positivity. METHODS: 1,733 subjects were included in this study. Genomic DNA was extracted from peripheral blood white cells. Four SNPs (rs11675434 [TPO], rs3094228 [HCP5], rs9277555 [HLA-DPB1], and rs301799 [RERE]) were selected for genotyping. Weighted TPOAb genetic risk score (GRS) was calculated based on these 4 SNPs. Thyroid hormones and autoimmune antibodies (TPOAb and thyroglobulin antibody) were determined using the electrochemiluminescence immunoassay method. RESULTS: The mean serum thyrotropin level in TPOAb-positive subjects was higher than in TPOAb-negative subjects (p < 0.01). Genotype GG of rs9277555 was associated with an increased risk of TPOAb positivity (OR = 1.64, 5-95% CI 1.09, 2.47, p = 0.02). Genotype TT of rs11675434 showed marginal increased risk of TPOAb positivity (OR = 1.57, 5-95% CI 1.01, 2.43, p = 0.048). Logistic regression analysis showed TPOAb-GRS and rs9277555 were associated with TPOAb positivity (OR = 5.09, 5-95% CI 1.30, 19.91, p = 0.02 and OR = 1.30, 5-95% CI 1.05, 1.61, p = 0.02). Subjects with a high TPOAb-GRS had a 52% increased risk of TPOAb positivity compared to subjects with a low TPOAb-GRS (OR 1.52, 5-95% CI 1.05, 2.21, p = 0.03). CONCLUSION: TPOAb-GRS was associated with an increased risk of TPOAb positivity in a Chinese Han population. This effect might be attribute to rs9277555.
Authors: Daniela M C Miranda; Juliana N Massom; Regina M Catarino; Raimunda T M Santos; Sônia S Toyoda; Marília M S Marone; Eduardo K Tomimori; Osmar Monte Journal: Thyroid Date: 2015-01 Impact factor: 6.568
Authors: Ulla T Schultheiss; Alexander Teumer; Marco Medici; Yong Li; Natalie Daya; Layal Chaker; Georg Homuth; Andre G Uitterlinden; Matthias Nauck; Albert Hofman; Elizabeth Selvin; Henry Völzke; Robin P Peeters; Anna Köttgen Journal: J Clin Endocrinol Metab Date: 2015-02-26 Impact factor: 5.958
Authors: J Sun; D Teng; C Li; S Peng; J Mao; W Wang; X Xie; C Fan; C Li; T Meng; S Zhang; J Du; Z Gao; Z Shan; W Teng Journal: J Endocrinol Invest Date: 2019-07-01 Impact factor: 4.256
Authors: Marco Medici; Eleonora Porcu; Giorgio Pistis; Alexander Teumer; Suzanne J Brown; Richard A Jensen; Rajesh Rawal; Greet L Roef; Theo S Plantinga; Sita H Vermeulen; Jari Lahti; Matthew J Simmonds; Lise Lotte N Husemoen; Rachel M Freathy; Beverley M Shields; Diana Pietzner; Rebecca Nagy; Linda Broer; Layal Chaker; Tim I M Korevaar; Maria Grazia Plia; Cinzia Sala; Uwe Völker; J Brent Richards; Fred C Sweep; Christian Gieger; Tanguy Corre; Eero Kajantie; Betina Thuesen; Youri E Taes; W Edward Visser; Andrew T Hattersley; Jürgen Kratzsch; Alexander Hamilton; Wei Li; Georg Homuth; Monia Lobina; Stefano Mariotti; Nicole Soranzo; Massimiliano Cocca; Matthias Nauck; Christin Spielhagen; Alec Ross; Alice Arnold; Martijn van de Bunt; Sandya Liyanarachchi; Margit Heier; Hans Jörgen Grabe; Corrado Masciullo; Tessel E Galesloot; Ee M Lim; Eva Reischl; Peter J Leedman; Sandra Lai; Alessandro Delitala; Alexandra P Bremner; David I W Philips; John P Beilby; Antonella Mulas; Matteo Vocale; Goncalo Abecasis; Tom Forsen; Alan James; Elisabeth Widen; Jennie Hui; Holger Prokisch; Ernst E Rietzschel; Aarno Palotie; Peter Feddema; Stephen J Fletcher; Katharina Schramm; Jerome I Rotter; Alexander Kluttig; Dörte Radke; Michela Traglia; Gabriela L Surdulescu; Huiling He; Jayne A Franklyn; Daniel Tiller; Bijay Vaidya; Tim de Meyer; Torben Jørgensen; Johan G Eriksson; Peter C O'Leary; Eric Wichmann; Ad R Hermus; Bruce M Psaty; Till Ittermann; Albert Hofman; Emanuele Bosi; David Schlessinger; Henri Wallaschofski; Nicola Pirastu; Yurii S Aulchenko; Albert de la Chapelle; Romana T Netea-Maier; Stephen C L Gough; Henriette Meyer Zu Schwabedissen; Timothy M Frayling; Jean-Marc Kaufman; Allan Linneberg; Katri Räikkönen; Johannes W A Smit; Lambertus A Kiemeney; Fernando Rivadeneira; André G Uitterlinden; John P Walsh; Christa Meisinger; Martin den Heijer; Theo J Visser; Timothy D Spector; Scott G Wilson; Henry Völzke; Anne Cappola; Daniela Toniolo; Serena Sanna; Silvia Naitza; Robin P Peeters Journal: PLoS Genet Date: 2014-02-27 Impact factor: 5.917