Literature DB >> 33777324

Cardiac Aging: From Basic Research to Therapeutics.

Mingjing Yan1,2, Shenghui Sun1, Kun Xu1, Xiuqing Huang1, Lin Dou1, Jing Pang1, Weiqing Tang1, Tao Shen1,2, Jian Li1,2.   

Abstract

With research progress on longevity, we have gradually recognized that cardiac aging causes changes in heart structure and function, including progressive myocardial remodeling, left ventricular hypertrophy, and decreases in systolic and diastolic function. Elucidating the regulatory mechanisms of cardiac aging is a great challenge for biologists and physicians worldwide. In this review, we discuss several key molecular mechanisms of cardiac aging and possible prevention and treatment methods developed in recent years. Insights into the process and mechanism of cardiac aging are necessary to protect against age-related diseases, extend lifespan, and reduce the increasing burden of cardiovascular disease in elderly individuals. We believe that research on cardiac aging is entering a new era of unique significance for the progress of clinical medicine and social welfare.
Copyright © 2021 Mingjing Yan et al.

Entities:  

Mesh：

Year:  2021        PMID： 33777324      PMCID： PMC7969106          DOI： 10.1155/2021/9570325

Source DB:  PubMed          Journal:  Oxid Med Cell Longev        ISSN： 1942-0994            Impact factor:   6.543


  151 in total

1.  Aging: a theory based on free radical and radiation chemistry.

Authors:  D HARMAN
Journal:  J Gerontol       Date:  1956-07

2.  Iron status and oxidative stress in the aged rabbit heart.

Authors:  Domenico Lapenna; Giuliano Ciofani; Sante Donato Pierdomenico; Maria Adele Giamberardino; Ettore Porreca
Journal:  J Mol Cell Cardiol       Date:  2017-11-24       Impact factor: 5.000

3.  Inhibition of autophagy in the heart induces age-related cardiomyopathy.

Authors:  Manabu Taneike; Osamu Yamaguchi; Atsuko Nakai; Shungo Hikoso; Toshihiro Takeda; Isamu Mizote; Takafumi Oka; Takahito Tamai; Jota Oyabu; Tomokazu Murakawa; Kazuhiko Nishida; Takahiko Shimizu; Masatsugu Hori; Issei Komuro; Takuji Shirasawa Takuji Shirasawa; Noboru Mizushima; Kinya Otsu
Journal:  Autophagy       Date:  2010-07-01       Impact factor: 16.016

4.  The biologic clock: the mitochondria?

Authors:  D Harman
Journal:  J Am Geriatr Soc       Date:  1972-04       Impact factor: 5.562

Review 5.  Cell Biology of the Mitochondrion.

Authors:  Alexander M van der Bliek; Margaret M Sedensky; Phil G Morgan
Journal:  Genetics       Date:  2017-11       Impact factor: 4.562

Review 6.  The Role of Autophagy in the Heart.

Authors:  Sebastiano Sciarretta; Yasuhiro Maejima; Daniela Zablocki; Junichi Sadoshima
Journal:  Annu Rev Physiol       Date:  2017-10-25       Impact factor: 19.318

Review 7.  From bench to FDA to bedside: US regulatory trends for new stem cell therapies.

Authors:  Paul S Knoepfler
Journal:  Adv Drug Deliv Rev       Date:  2014-12-07       Impact factor: 15.470

8.  Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.

Authors:  Pankaj Shende; Lifen Xu; Christian Morandi; Laura Pentassuglia; Philippe Heim; Sonia Lebboukh; Corinne Berthonneche; Thierry Pedrazzini; Beat A Kaufmann; Michael N Hall; Markus A Rüegg; Marijke Brink
Journal:  Cardiovasc Res       Date:  2015-11-23       Impact factor: 10.787

9.  Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Authors:  Rong Wang; Zhen Yu; Bharath Sunchu; James Shoaf; Ivana Dang; Stephanie Zhao; Kelsey Caples; Lynda Bradley; Laura M Beaver; Emily Ho; Christiane V Löhr; Viviana I Perez
Journal:  Aging Cell       Date:  2017-03-31       Impact factor: 9.304

10.  TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging.

Authors:  Guoliang Lyu; Yiting Guan; Chao Zhang; Le Zong; Lei Sun; Xiaoke Huang; Li Huang; Lijun Zhang; Xiao-Li Tian; Zhongjun Zhou; Wei Tao
Journal:  Nat Commun       Date:  2018-07-02       Impact factor: 14.919
View more
  4 in total

1.  Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules.

Authors:  Naser Mahdavi; Siyavash Joukar; Hamid Najafipour; Vida Naderi-Boldaji
Journal:  Pflugers Arch       Date:  2022-05-16       Impact factor: 4.458

2.  Ferulic Acid Alleviates Oxidative Stress-Induced Cardiomyocyte Injury by the Regulation of miR-499-5p/p21 Signal Cascade.

Authors:  Shenghui Sun; Yang Ruan; Mingjing Yan; Kun Xu; Yao Yang; Tao Shen; Zening Jin
Journal:  Evid Based Complement Alternat Med       Date:  2021-12-07       Impact factor: 2.629

3.  miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxicity by Inhibiting CyclinG1.

Authors:  Mingjing Yan; Yuan Cao; Que Wang; Kun Xu; Lin Dou; Xiuqing Huang; Beidong Chen; Weiqing Tang; Ming Lan; Bing Liu; Kaiyi Zhu; Yao Yang; Shenghui Sun; Xiyue Zhang; Yong Man; Mingyan Hei; Tao Shen; Jian Li
Journal:  Oxid Med Cell Longev       Date:  2022-02-10       Impact factor: 6.543

4.  Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals.

Authors:  Shintarou Kimura; Misa Ichikawa; Suzuka Sugawara; Tomoko Katagiri; Yuumi Hirasawa; Takahiro Ishikawa; Wataru Matsunaga; Akinobu Gotoh
Journal:  Cureus       Date:  2022-09-05
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.