Suzana Tihić-Kapidžić1, Adlija Čaušević2, Jasmina Fočo-Solak1, Maja Malenica2, Tanja Dujić2, Sniježana Hasanbegović3, Nermina Babić4, Ermin Begović1. 1. University of Sarajevo, Clinical Centre, Department for Clinical Biochemistry and Immunology, Sarajevo, Bosnia and Herzegovina. 2. University of Sarajevo, Faculty of Pharmacy, Department of Biochemistry and Clinical Analysis, Sarajevo, Bosnia and Herzegovina. 3. Clinical Centre University of Sarajevo, Pediatric Clinic, Sarajevo, Bosnia and Herzegovina. 4. University of Sarajevo, Medical Faculty, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina.
Abstract
BACKGROUND: Altered levels of many hematological parameters have been directly associated with diabetes in adults, while studies on children with type 1 diabetes mellitus are lacking. The aim of this study was to determine hematological indices in diabetic Bosnian children in comparison to healthy controls as well as to correlate their levels to blood glucose and hemoglobin A1c. METHODS: 100 healthy and 100 children with type 1 diabetes mellitus (age 1-18) were included in this study. Complete blood count, hemoglobin A1c, and glucose were tested. Results were analysed by IBM SPSS Statistics version 23. RESULTS: Significant differences (p<0.05) between healthy and diabetic children were found in relation to HbA1c, glucose, mean platelet volume, the number of white blood cells and erythrocytes, hematocrit, hemoglobin and MCH values. No gender differences or significant age differences were seen for hemoglobin, hematocrit, and MCV, while platelets, MPV, and MCH differed by age only in healthy children. When diabetic children were classified according to HbA1c levels, significant differences were seen for erythrocyte count and hematocrit value (p=0.013 and 0.019, respectively). The number of erythrocytes and white blood cells correlated significantly with HbA1c (p=0.037 and 0.027, respectively). CONCLUSIONS: Lower levels of erythrocytes, hematocrit, and hemoglobin in diabetic compared to healthy children indicate possible development of anemia, while higher MCV, MCH, and MPV values indicate an alteration in erythrocyte morphology. Hematological indices could be a useful inexpensive tool in the diagnosis and follow up of type 1 diabetes in children. 2021 Suzana Tihić-Kapidžić, Adlija Čaušević, Jasmina Fočo-Solak, Maja Malenica, Tanja Dujić, Sniježana Hasanbegović, Nermina Babić, Ermin Begović, published by CEON/CEES.
BACKGROUND: Altered levels of many hematological parameters have been directly associated with diabetes in adults, while studies on children with type 1 diabetes mellitus are lacking. The aim of this study was to determine hematological indices in diabetic Bosnian children in comparison to healthy controls as well as to correlate their levels to blood glucose and hemoglobin A1c. METHODS: 100 healthy and 100 children with type 1 diabetes mellitus (age 1-18) were included in this study. Complete blood count, hemoglobin A1c, and glucose were tested. Results were analysed by IBM SPSS Statistics version 23. RESULTS: Significant differences (p<0.05) between healthy and diabetic children were found in relation to HbA1c, glucose, mean platelet volume, the number of white blood cells and erythrocytes, hematocrit, hemoglobin and MCH values. No gender differences or significant age differences were seen for hemoglobin, hematocrit, and MCV, while platelets, MPV, and MCH differed by age only in healthy children. When diabetic children were classified according to HbA1c levels, significant differences were seen for erythrocyte count and hematocrit value (p=0.013 and 0.019, respectively). The number of erythrocytes and white blood cells correlated significantly with HbA1c (p=0.037 and 0.027, respectively). CONCLUSIONS: Lower levels of erythrocytes, hematocrit, and hemoglobin in diabetic compared to healthy children indicate possible development of anemia, while higher MCV, MCH, and MPV values indicate an alteration in erythrocyte morphology. Hematological indices could be a useful inexpensive tool in the diagnosis and follow up of type 1 diabetes in children. 2021 Suzana Tihić-Kapidžić, Adlija Čaušević, Jasmina Fočo-Solak, Maja Malenica, Tanja Dujić, Sniježana Hasanbegović, Nermina Babić, Ermin Begović, published by CEON/CEES.