A S Gersing1, B J Schwaiger2, M C Nevitt3, G B Joseph4, G Feuerriegel5, P M Jungmann6, J B Guimaraes7, L Facchetti8, C E McCulloch9, M R Makowski10, T M Link11. 1. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Radiology, School of Medicine, Technical University of Munich, Munich, Germany; Department of Neuroradiology, University Hospital, LMU Munich, Munich, Germany. Electronic address: alexandra.gersing@tum.de. 2. Department of Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany. Electronic address: benedikt.schwaiger@tum.de. 3. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: MNevitt@psg.ucsf.edu. 4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: Gabby.Joseph@ucsf.edu. 5. Department of Radiology, School of Medicine, Technical University of Munich, Munich, Germany. Electronic address: georg.feuerriegel@tum.de. 6. Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: pia.jungmann@uniklinik-freiburg.de. 7. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: Julio.BrandaoGuimaraes@ucsf.edu. 8. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: facchettil@gmail.com. 9. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: Charles.McCulloch@ucsf.edu. 10. Department of Radiology, School of Medicine, Technical University of Munich, Munich, Germany. Electronic address: marcus.makowski@tum.de. 11. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: Thomas.Link@ucsf.edu.
Abstract
OBJECTIVE: To compare progression over 8 years in knee compositional cartilage degeneration and structural joint abnormalities in knees with different types of anterior cruciate ligament (ACL) abnormalities over 8 years. METHOD: Baseline MR images of the right knees of 1899 individuals of the Osteoarthritis Initiative (OAI) with no evidence of or mild to moderate radiographic osteoarthritis were assessed for nontraumatic ACL abnormalities. The knees of 91 individuals showed nontraumatic ACL abnormalities (age 60.6 ± 9.8 y, 46 females; mucoid degeneration (MD), N = 37; complete tear (CT), N = 22; partial tear (PT), N = 32) and were frequency-matched to 91 individuals with normal ACL. MRIs were assessed for knee joint abnormalities using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) and cartilage T2 mapping at baseline, 4- and 8-year follow-up. RESULTS: Over 8 years, cartilage T2 values of the medial tibia showed a significantly greater increase in individuals with MD, PT or CT compared to those with normal ACL (adjusted rate of change/year [95% confidence interval], normal ACL: 0.06 [0.01, 0.23], MD: 0.34 [0.07, 0.73], PT, 0.21 [0.02, 0.33], CT, 0.51 [0.16, 0.78]), indicating an association of ACL abnormalities and an increased progression rate of cartilage degeneration in subjects with and without knee joint degeneration. This effect was also seen in cartilage T2 values averaged over all compartments (normal ACL: 0.08 [0.05, 0.20] vs abnormal ACL: 0.27 [0.06, 0.56]). CONCLUSIONS: Over 8 years, higher progression rates of cartilage degeneration, especially in the medial tibia, were associated with ACL abnormalities compared to those with normal ACL, in subjects with and without knee joint abnormalities.
OBJECTIVE: To compare progression over 8 years in knee compositional cartilage degeneration and structural joint abnormalities in knees with different types of anterior cruciate ligament (ACL) abnormalities over 8 years. METHOD: Baseline MR images of the right knees of 1899 individuals of the Osteoarthritis Initiative (OAI) with no evidence of or mild to moderate radiographic osteoarthritis were assessed for nontraumatic ACL abnormalities. The knees of 91 individuals showed nontraumatic ACL abnormalities (age 60.6 ± 9.8 y, 46 females; mucoid degeneration (MD), N = 37; complete tear (CT), N = 22; partial tear (PT), N = 32) and were frequency-matched to 91 individuals with normal ACL. MRIs were assessed for knee joint abnormalities using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) and cartilage T2 mapping at baseline, 4- and 8-year follow-up. RESULTS: Over 8 years, cartilage T2 values of the medial tibia showed a significantly greater increase in individuals with MD, PT or CT compared to those with normal ACL (adjusted rate of change/year [95% confidence interval], normal ACL: 0.06 [0.01, 0.23], MD: 0.34 [0.07, 0.73], PT, 0.21 [0.02, 0.33], CT, 0.51 [0.16, 0.78]), indicating an association of ACL abnormalities and an increased progression rate of cartilage degeneration in subjects with and without knee joint degeneration. This effect was also seen in cartilage T2 values averaged over all compartments (normal ACL: 0.08 [0.05, 0.20] vs abnormal ACL: 0.27 [0.06, 0.56]). CONCLUSIONS: Over 8 years, higher progression rates of cartilage degeneration, especially in the medial tibia, were associated with ACL abnormalities compared to those with normal ACL, in subjects with and without knee joint abnormalities.
Authors: G B Joseph; C E McCulloch; M C Nevitt; U Heilmeier; L Nardo; J A Lynch; F Liu; T Baum; T M Link Journal: Osteoarthritis Cartilage Date: 2015-02-11 Impact factor: 6.576
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Authors: M Kretzschmar; U Heilmeier; A Yu; G B Joseph; F Liu; M Solka; C E McCulloch; M C Nevitt; T M Link Journal: Osteoarthritis Cartilage Date: 2016-03-10 Impact factor: 6.576
Authors: P M Jungmann; M S Kraus; H Alizai; L Nardo; T Baum; M C Nevitt; C E McCulloch; G B Joseph; J A Lynch; T M Link Journal: Arthritis Care Res (Hoboken) Date: 2013-12 Impact factor: 4.794
Authors: A S Gersing; M Solka; G B Joseph; B J Schwaiger; U Heilmeier; G Feuerriegel; M C Nevitt; C E McCulloch; T M Link Journal: Osteoarthritis Cartilage Date: 2016-01-30 Impact factor: 6.576
Authors: A S Gersing; B J Schwaiger; M C Nevitt; J Zarnowski; G B Joseph; G Feuerriegel; P M Jungmann; J B Guimaraes; L Facchetti; C E McCulloch; T M Link Journal: Osteoarthritis Cartilage Date: 2019-02-28 Impact factor: 6.576