Literature DB >> 3377450

Stimulation of lipolytic enzymes in Alzheimer's disease.

A A Farooqui1, L Liss, L A Horrocks.   

Abstract

The activities of monoacylglycerol and diacylglycerol lipases were 6 to 8 times higher in plasma membrane and synaptosomal plasma membrane fractions of nucleus basalis from patients with Alzheimer's disease than in those membranes from normal human brains. Membranes from the hippocampus region of Alzheimer-affected brains also showed consistently higher activities of monoacylglycerol and diacylglycerol lipases than those from control brains. These results indicate a stimulation of lipolytic enzymes in nucleus basalis and hippocampus regions in patients with Alzheimer's disease.

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Year:  1988        PMID： 3377450     DOI： 10.1002/ana.410230317

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  7 in total

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Review 7.  Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases.

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