Literature DB >> 33773899

Gain of 'FAOnction', Loss of Fibrosis.

Rebekah J Nicholson1, Nirupama Ramkumar2, Scott A Summers3.   

Abstract

Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, mitochondrial dynamics, and tubular epithelial cell (TEC) differentiation, while upregulation of FAO in kidney tubules provided protection from kidney fibrosis and functional decline.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  chronic kidney disease; fatty acid oxidation; kidney fibrosis; tubular epithelial cell

Mesh：

Year:  2021        PMID： 33773899      PMCID： PMC8947942          DOI： 10.1016/j.tem.2021.03.005

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   10.586


  8 in total

1.  Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells.

Authors:  W Lieberthal; S A Menza; J S Levine
Journal:  Am J Physiol       Date:  1998-02

Review 2.  Developing Treatments for Chronic Kidney Disease in the 21st Century.

Authors:  Matthew D Breyer; Katalin Susztak
Journal:  Semin Nephrol       Date:  2016-11       Impact factor: 5.299

3.  Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction.

Authors:  A Miyajima; J Chen; C Lawrence; S Ledbetter; R A Soslow; J Stern; S Jha; J Pigato; M L Lemer; D P Poppas; E D Vaughan; D Felsen
Journal:  Kidney Int       Date:  2000-12       Impact factor: 10.612

4.  Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis.

Authors:  Verónica Miguel; Jessica Tituaña; J Ignacio Herrero; Laura Herrero; Dolors Serra; Paula Cuevas; Coral Barbas; Diego Rodríguez Puyol; Laura Márquez-Expósito; Marta Ruiz-Ortega; Carolina Castillo; Xin Sheng; Katalin Susztak; Miguel Ruiz-Canela; Jordi Salas-Salvadó; Miguel A Martínez González; Sagrario Ortega; Ricardo Ramos; Santiago Lamas
Journal:  J Clin Invest       Date:  2021-03-01       Impact factor: 14.808

5.  Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development.

Authors:  Hyun Mi Kang; Seon Ho Ahn; Peter Choi; Yi-An Ko; Seung Hyeok Han; Frank Chinga; Ae Seo Deok Park; Jianling Tao; Kumar Sharma; James Pullman; Erwin P Bottinger; Ira J Goldberg; Katalin Susztak
Journal:  Nat Med       Date:  2014-12-01       Impact factor: 53.440

Review 6.  Cellular and molecular mechanisms of kidney fibrosis.

Authors:  Sonja Djudjaj; Peter Boor
Journal:  Mol Aspects Med       Date:  2018-06-22

7.  Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.

Authors:  Craig Brooks; Qingqing Wei; Sung-Gyu Cho; Zheng Dong
Journal:  J Clin Invest       Date:  2009-04-06       Impact factor: 14.808

8.  The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Authors:  Poonam Dhillon; Jihwan Park; Carmen Hurtado Del Pozo; Lingzhi Li; Tomohito Doke; Shizheng Huang; Juanjuan Zhao; Hyun Mi Kang; Rojesh Shrestra; Michael S Balzer; Shatakshee Chatterjee; Patricia Prado; Seung Yub Han; Hongbo Liu; Xin Sheng; Pieterjan Dierickx; Kirill Batmanov; Juan P Romero; Felipe Prósper; Mingyao Li; Liming Pei; Junhyong Kim; Nuria Montserrat; Katalin Susztak
Journal:  Cell Metab       Date:  2020-12-09       Impact factor: 31.373
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.