BACKGROUND: COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). AIMS: Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. MATERIALS & METHODS: PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. RESULTS: Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P < .0001) and age (P = .0202) for thrombotic events in patients diagnosed with COVID-19. CONCLUSION: Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.
BACKGROUND:COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). AIMS: Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. MATERIALS & METHODS: PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. RESULTS: Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P < .0001) and age (P = .0202) for thrombotic events in patients diagnosed with COVID-19. CONCLUSION:Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.
Authors: B de Laat; M J M Traets; R W M De Laat-Kremers; S P Verweij; M Ninivaggi; E Jong; D Huskens; B A Blok; G C P Remme; A Miszta; R H T Nijhuis; G J M Herder; R Fijnheer; M Roest; A T L Fiolet; J A Remijn Journal: PLoS One Date: 2022-04-28 Impact factor: 3.752
Authors: Fabio Augusto Rodrigues Gonçalves; Bruno Adler Maccagnan Pinheiro Besen; Clarice Antunes de Lima; Aline Pivetta Corá; Antônio José Rodrigues Pereira; Sandro Félix Perazzio; Christiane Pereira Gouvea; Luiz Augusto Marcondes Fonseca; Evelinda Marramon Trindade; Nairo Massakazu Sumita; Alberto José da Silva Duarte; Arnaldo Lichtenstein; Eloisa Bonfa; Edivaldo M Utiyama; Aluisio C Segurado; Beatriz Perondi; Anna Miethke-Morais; Amanda C Montal; Leila Harima; Solange R G Fusco; Marjorie F Silva; Marcelo C Rocha; Izabel Marcilio; Izabel Cristina Rios; Fabiane Yumi Ogihara Kawano; Maria Amélia de Jesus; Ésper George Kallas; Carolina Carmo; Clarice Tanaka; Heraldo Possolo de Souza; Julio F M Marchini; Carlos Carvalho; Juliana C Ferreira; Anna Sara Shafferman Levin; Maura Salaroli Oliveira; Thaís Guimarães; Carolina Dos Santos Lázari; Ester Sabino; Marcello M C Magri; Tarcisio E P Barros-Filho; Maria Cristina Peres Braido Francisco; Silvia F Costa Journal: Clinics (Sao Paulo) Date: 2021-12-08 Impact factor: 2.365
Authors: Yvonne Goßlau; Tobias Dominik Warm; Edgar Franklin Hernandez Cancino; Inge Kirchberger; Christine Meisinger; Jakob Linseisen; Alexander Hyhlik-Duerr Journal: Wien Med Wochenschr Date: 2022-08-08
Authors: Dominik F Draxler; Justine Brodard; Björn Zante; Stephan M Jakob; Jan Wiegand; Johanna A Kremer Hovinga; Anne Angelillo-Scherrer; Alicia Rovo Journal: Thromb J Date: 2022-09-26