| Literature DB >> 33772031 |
Yijian Li1,2, Lingling Ge3,4, Xia Chen3,4,5, Yumei Mao6, Xianliang Gu3,4, Bangqi Ren3,4, Yuxiao Zeng3,4, Min Chen3,4, Siyu Chen3,4, Jinhua Liu3,4, Yuli Yang7,8, Haiwei Xu9,10.
Abstract
Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LESCs-independent. Here, using rat corneal epithelial wounds with different sizes, we show that YAP activation promotes the activation and expansion of LESCs after a large wound, as well as the reprogramming of local epithelial cells (repairing epithelial cells) after a small wound, which contributes to LESCs-dependent and -independent wound healing, respectively. Mechanically, we highlight that the reciprocal regulation of YAP activity and the assembly of cell junction and cortical F-actin cytoskeleton accelerates corneal epithelial healing with different-sized wounds. Together, the common YAP activation and the underlying regulatory mechanism are harnessed by LESCs and lineage-restricted epithelial cells to cope with corneal epithelial wounds with different sizes.Entities:
Year: 2021 PMID： 33772031 PMCID： PMC7997881 DOI： 10.1038/s41536-021-00126-2
Source DB: PubMed Journal: NPJ Regen Med ISSN： 2057-3995