Literature DB >> 33771353

Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display.

Hayden Peacock1, Hiroaki Suga2.   

Abstract

Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery of macrocyclic peptides. This article reviews the current approaches for generating macrocyclic peptide libraries using mRNA display and highlights some recent examples of ribosomal incorporation of nonproteinogenic amino acids into macrocyclic peptides.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords:  drug discovery; in vitro translation; macrocyclic peptides; protein–protein interactions

Year:  2021        PMID： 33771353     DOI： 10.1016/j.tips.2021.02.004

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  4 in total

Review 1.  Targeting intracellular protein-protein interactions with macrocyclic peptides.

Authors:  Marina Buyanova; Dehua Pei
Journal:  Trends Pharmacol Sci       Date:  2021-12-13       Impact factor: 14.819

2.  Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale.

Authors:  Sevan Habeshian; Manuel Leonardo Merz; Gontran Sangouard; Ganesh Kumar Mothukuri; Mischa Schüttel; Zsolt Bognár; Cristina Díaz-Perlas; Jonathan Vesin; Julien Bortoli Chapalay; Gerardo Turcatti; Laura Cendron; Alessandro Angelini; Christian Heinis
Journal:  Nat Commun       Date:  2022-07-02       Impact factor: 17.694

3.  Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.

Authors:  Shuhui Lim; Nicolas Boyer; Nicole Boo; Chunhui Huang; Gireedhar Venkatachalam; Yu-Chi Angela Juang; Michael Garrigou; Hung Yi Kristal Kaan; Ruchia Duggal; Khong Ming Peh; Ahmad Sadruddin; Pooja Gopal; Tsz Ying Yuen; Simon Ng; Srinivasaraghavan Kannan; Christopher J Brown; Chandra S Verma; Peter Orth; Andrea Peier; Lan Ge; Xiang Yu; Bhavana Bhatt; Feifei Chen; Erjia Wang; Nianyu Jason Li; Raymond J Gonzales; Alexander Stoeck; Brian Henry; Tomi K Sawyer; David P Lane; Charles W Johannes; Kaustav Biswas; Anthony W Partridge
Journal:  Chem Sci       Date:  2021-11-25       Impact factor: 9.825

4.  Antiviral cyclic peptides targeting the main protease of SARS-CoV-2.

Authors:  Jason Johansen-Leete; Sven Ullrich; Sarah E Fry; Rebecca Frkic; Max J Bedding; Anupriya Aggarwal; Anneliese S Ashhurst; Kasuni B Ekanayake; Mithun C Mahawaththa; Vishnu M Sasi; Stephanie Luedtke; Daniel J Ford; Anthony J O'Donoghue; Toby Passioura; Mark Larance; Gottfried Otting; Stuart Turville; Colin J Jackson; Christoph Nitsche; Richard J Payne
Journal:  Chem Sci       Date:  2022-02-28       Impact factor: 9.825
  4 in total

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