Literature DB >> 33771156

Fibroblasts in cancer dormancy: foe or friend?

Li Dai1, Mao Li1, Wei-Long Zhang1, Ya-Jie Tang2, Ya-Ling Tang3, Xin-Hua Liang4.   

Abstract

Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis.

Entities:  

Keywords:  CAF; Cancer dormancy; Cancer therapy; Fibroblast; Senescence

Year:  2021        PMID： 33771156      PMCID： PMC7995785          DOI： 10.1186/s12935-021-01883-2

Source DB:  PubMed          Journal:  Cancer Cell Int        ISSN： 1475-2867            Impact factor:   5.722


  93 in total

1.  Cancer without disease.

Authors:  Judah Folkman; Raghu Kalluri
Journal:  Nature       Date:  2004-02-26       Impact factor: 49.962

2.  Modulation of growth of a human prostatic cancer cell line (PC-3) in agar culture by normal human lung fibroblasts.

Authors:  D Kirk; M F Szalay; M E Kaighn
Journal:  Cancer Res       Date:  1981-03       Impact factor: 12.701

3.  Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth.

Authors:  Xiangnan Guan; Kyle M LaPak; Rebecca C Hennessey; Christina Y Yu; Reena Shakya; Jianying Zhang; Christin E Burd
Journal:  Mol Cancer Res       Date:  2016-12-30       Impact factor: 5.852

4.  The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites.

Authors:  Hua Gao; Goutam Chakraborty; Ai Ping Lee-Lim; Qianxing Mo; Markus Decker; Alin Vonica; Ronglai Shen; Edi Brogi; Ali H Brivanlou; Filippo G Giancotti
Journal:  Cell       Date:  2012-08-17       Impact factor: 41.582

5.  Autophagy mediates the mitotic senescence transition.

Authors:  Andrew R J Young; Masako Narita; Manuela Ferreira; Kristina Kirschner; Mahito Sadaie; Jeremy F J Darot; Simon Tavaré; Satoko Arakawa; Shigeomi Shimizu; Fiona M Watt; Masashi Narita
Journal:  Genes Dev       Date:  2009-03-11       Impact factor: 11.361

6.  TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis.

Authors:  Xing Qin; Ming Yan; Jianjun Zhang; Xu Wang; Zongze Shen; Zhongjing Lv; Zhihui Li; Wenyi Wei; Wantao Chen
Journal:  Sci Rep       Date:  2016-02-09       Impact factor: 4.379

7.  Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.

Authors:  Pasquale Sansone; Claudio Ceccarelli; Marjan Berishaj; Qing Chang; Vinagolu K Rajasekhar; Fabiana Perna; Robert L Bowman; Michele Vidone; Laura Daly; Jennifer Nnoli; Donatella Santini; Mario Taffurelli; Natalie N C Shih; Michael Feldman; Jun J Mao; Christopher Colameco; Jinbo Chen; Angela DeMichele; Nicola Fabbri; John H Healey; Monica Cricca; Giuseppe Gasparre; David Lyden; Massimiliano Bonafé; Jacqueline Bromberg
Journal:  Nat Commun       Date:  2016-02-09       Impact factor: 14.919

Review 8.  Antifibrotic therapy to normalize the tumor microenvironment.

Authors:  Anette Hauge; Einar K Rofstad
Journal:  J Transl Med       Date:  2020-05-20       Impact factor: 5.531

9.  Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.

Authors:  Nicola Aceto; Aditya Bardia; David T Miyamoto; Maria C Donaldson; Ben S Wittner; Joel A Spencer; Min Yu; Adam Pely; Amanda Engstrom; Huili Zhu; Brian W Brannigan; Ravi Kapur; Shannon L Stott; Toshi Shioda; Sridhar Ramaswamy; David T Ting; Charles P Lin; Mehmet Toner; Daniel A Haber; Shyamala Maheswaran
Journal:  Cell       Date:  2014-08-28       Impact factor: 41.582

10.  Dermal fibroblasts induce cell cycle arrest and block epithelial-mesenchymal transition to inhibit the early stage melanoma development.

Authors:  Linli Zhou; Kun Yang; R Randall Wickett; Yuhang Zhang
Journal:  Cancer Med       Date:  2016-04-06       Impact factor: 4.452
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  2 in total

Review 1.  Metabolic Features of Tumor Dormancy: Possible Therapeutic Strategies.

Authors:  Erica Pranzini; Giovanni Raugei; Maria Letizia Taddei
Journal:  Cancers (Basel)       Date:  2022-01-21       Impact factor: 6.639

2.  Transcriptomics and Metabolomics Identify Drug Resistance of Dormant Cell in Colorectal Cancer.

Authors:  Lang Xie; Renli Huang; Hongyun Huang; Xiaoxia Liu; Jinlong Yu
Journal:  Front Pharmacol       Date:  2022-04-08       Impact factor: 5.988
  2 in total

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