Literature DB >> 33769252

Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021.

Sathyavani Subbarao1, Lenesha A Warrener2, Katja Hoschler2, Keith R Perry2, Justin Shute2, Heather Whitaker3, Michelle O'Brien4, Frances Baawuah1,4, Paul Moss5, Helen Parry5, Shamez N Ladhani1,6, Mary E Ramsay1, Kevin E Brown1, Gayatri Amirthalingam1.   

Abstract

Sera were collected from 185 adults aged ≥ 70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in > 94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom's approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.

Entities:  

Keywords:  Antibody; COVID-19; COVID-Vaccine; Immunity; Pfizer/BioNtech; Spike Protein

Mesh：

Substances：

Year:  2021        PMID： 33769252      PMCID： PMC7995559          DOI： 10.2807/1560-7917.ES.2021.26.12.2100329

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


  2 in total

1.  BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting.

Authors:  Noa Dagan; Noam Barda; Eldad Kepten; Oren Miron; Shay Perchik; Mark A Katz; Miguel A Hernán; Marc Lipsitch; Ben Reis; Ran D Balicer
Journal:  N Engl J Med       Date:  2021-02-24       Impact factor: 91.245

2.  Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021.

Authors:  Kamal Abu Jabal; Hila Ben-Amram; Karine Beiruti; Yunis Batheesh; Christian Sussan; Salman Zarka; Michael Edelstein
Journal:  Euro Surveill       Date:  2021-02
  2 in total
  14 in total

1.  Impact of COVID-19 vaccination program on seroprevalence in blood donors in England, 2021.

Authors:  Heather J Whitaker; Suzanne Elgohari; Cathy Rowe; Ashley David Otter; Tim Brooks; Ezra Linley; Iain Hayden; Sonia Ribeiro; Jacqueline Hewson; Anissa Lakhani; Eleanor Clarke; Camille Tsang; Colin Nj Campbell; Mary Ramsay; Kevin Brown; Gayatri Amirthalingam
Journal:  J Infect       Date:  2021-05-11       Impact factor: 6.072

2.  Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals.

Authors:  Katie Healy; Elisa Pin; Puran Chen; Gunnar Söderdahl; Piotr Nowak; Stephan Mielke; Lotta Hansson; Peter Bergman; C I Edvard Smith; Per Ljungman; Davide Valentini; Ola Blennow; Anders Österborg; Giorgio Gabarrini; Khaled Al-Manei; Hassan Alkharaan; Michał Jacek Sobkowiak; Jamil Yousef; Sara Mravinacova; Angelica Cuapio; Xinling Xu; Mira Akber; Karin Loré; Cecilia Hellström; Sandra Muschiol; Gordana Bogdanovic; Marcus Buggert; Hans-Gustaf Ljunggren; Sophia Hober; Peter Nilsson; Soo Aleman; Margaret Sällberg Chen
Journal:  Med (N Y)       Date:  2022-01-20

3.  Assessment of Post-Vaccination Antibody Response Eight Months after the Administration of BNT1622b2 Vaccine to Healthcare Workers with Particular Emphasis on the Impact of Previous COVID-19 Infection.

Authors:  Blanka Wolszczak-Biedrzycka; Anna Bieńkowska; Justyna Dorf
Journal:  Vaccines (Basel)       Date:  2021-12-20

4.  Serological responses to COVID-19 Comirnaty booster vaccine, London, United Kingdom, September to December 2021.

Authors:  Georgina Ireland; Heather Whitaker; Shamez N Ladhani; Frances Baawuah; Sathyvani Subbarao; Ezra Linley; Lenesha Warrener; Michelle O'Brien; Corinne Whillock; Oliver Martin; Paul Moss; Mary E Ramsay; Gayatri Amirthalingam; Kevin E Brown
Journal:  Euro Surveill       Date:  2022-01

5.  Reinfection with new variants of SARS-CoV-2 after natural infection: a prospective observational cohort in 13 care homes in England.

Authors:  Anna Jeffery-Smith; Thomas A J Rowland; Monika Patel; Heather Whitaker; Nalini Iyanger; Sarah V Williams; Rebecca Giddings; Leah Thompson; Maria Zavala; Felicity Aiano; Joanna Ellis; Angie Lackenby; Katja Höschler; Kevin Brown; Mary E Ramsay; Robin Gopal; J Yimmy Chow; Shamez N Ladhani; Maria Zambon
Journal:  Lancet Healthy Longev       Date:  2021-12-01

6.  Serological responses and vaccine effectiveness for extended COVID-19 vaccine schedules in England.

Authors:  Gayatri Amirthalingam; Jamie Lopez Bernal; Nick J Andrews; Heather Whitaker; Charlotte Gower; Julia Stowe; Elise Tessier; Sathyavani Subbarao; Georgina Ireland; Frances Baawuah; Ezra Linley; Lenesha Warrener; Michelle O'Brien; Corinne Whillock; Paul Moss; Shamez N Ladhani; Kevin E Brown; Mary E Ramsay
Journal:  Nat Commun       Date:  2021-12-10       Impact factor: 14.919

7.  Anti-SARS-CoV-2 Receptor-Binding Domain Total Antibodies Response in Seropositive and Seronegative Healthcare Workers Undergoing COVID-19 mRNA BNT162b2 Vaccination.

Authors:  Gian Luca Salvagno; Brandon M Henry; Giovanni di Piazza; Laura Pighi; Simone De Nitto; Damiano Bragantini; Gian Luca Gianfilippi; Giuseppe Lippi
Journal:  Diagnostics (Basel)       Date:  2021-05-04

8.  Anti-SARS-CoV-2 Antibodies Testing in Recipients of COVID-19 Vaccination: Why, When, and How?

Authors:  Giuseppe Lippi; Brandon Michael Henry; Mario Plebani
Journal:  Diagnostics (Basel)       Date:  2021-05-25

9.  Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom.

Authors:  Koen B Pouwels; David W Eyre; A Sarah Walker; Jia Wei; Nicole Stoesser; Philippa C Matthews; Daniel Ayoubkhani; Ruth Studley; Iain Bell; John I Bell; John N Newton; Jeremy Farrar; Ian Diamond; Emma Rourke; Alison Howarth; Brian D Marsden; Sarah Hoosdally; E Yvonne Jones; David I Stuart; Derrick W Crook; Tim E A Peto
Journal:  Nat Microbiol       Date:  2021-07-21       Impact factor: 17.745

10.  Initial SARS-CoV-2 vaccination response can predict booster response for BNT162b2 but not for AZD1222.

Authors:  Thomas Perkmann; Nicole Perkmann-Nagele; Patrick Mucher; Astrid Radakovics; Manuela Repl; Thomas Koller; Galateja Jordakieva; Oswald F Wagner; Christoph J Binder; Helmuth Haslacher
Journal:  Int J Infect Dis       Date:  2021-07-28       Impact factor: 3.623
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