Literature DB >> 33768543

Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19.

Anno Saris1, Tom D Y Reijnders1, Martine Reijm2, Jolien C Hollander2, Kim de Buck2, Alex R Schuurman1, JanWillem Duitman1, Leo Heunks3, Jurjan Aman4, Harm Jan Bogaard4, Esther J Nossent4, Tom van der Poll1,5, Hetty J Bontkes2.   

Abstract

Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. ​.
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

Entities:  

Keywords:  CCL20; CCR6; COVID-19; T cells

Year:  2021        PMID： 33768543     DOI： 10.1002/eji.202049046

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  9 in total

1.  Human-host transcriptomic analysis reveals unique early innate immune responses in different sub-phenotypes of COVID-19.

Authors:  Ranjeet Maurya; Uzma Shamim; Partha Chattopadhyay; Priyanka Mehta; Pallavi Mishra; Priti Devi; Aparna Swaminathan; Sheeba Saifi; Kriti Khare; Aanchal Yadav; Shaista Parveen; Pooja Sharma; Vivekanand A; Akansha Tyagi; Vinita Jha; Bansidhar Tarai; Sujeet Jha; Mohd Faruq; Sandeep Budhiraja; Rajesh Pandey
Journal:  Clin Transl Med       Date:  2022-06

2.  Exploring SARS-CoV2 host-pathogen interactions and associated fungal infections cross-talk: Screening of targets and understanding pathogenesis.

Authors:  Abdul Arif Khan; Sudhir K Jain; Mahendra Rai; Samiran Panda
Journal:  Comput Struct Biotechnol J       Date:  2022-08-10       Impact factor: 6.155

3.  SARS-CoV-2-specific CD4+ T cell longevity correlates with Th17-like phenotype.

Authors:  Kazutaka Terahara; Takashi Sato; Yu Adachi; Keisuke Tonouchi; Taishi Onodera; Saya Moriyama; Lin Sun; Tomohiro Takano; Ayae Nishiyama; Ai Kawana-Tachikawa; Tetsuro Matano; Takayuki Matsumura; Masaharu Shinkai; Masanori Isogawa; Yoshimasa Takahashi
Journal:  iScience       Date:  2022-08-17

4.  Single-cell immune profiling reveals long-term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID-19 hospitalization.

Authors:  William J Pandori; Lindsey E Padgett; Ahmad Alimadadi; Norma A Gutierrez; Daniel J Araujo; Christine J Huh; Claire E Olingy; Huy Q Dinh; Runpei Wu; Pandurangan Vijayanand; Serena J Chee; Christian H Ottensmeier; Catherine C Hedrick
Journal:  J Leukoc Biol       Date:  2022-07-22       Impact factor: 6.011

5.  SARS-CoV-2-reactive IFN-γ-producing CD4+ and CD8+ T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients.

Authors:  Beatriz Olea; Eliseo Albert; Estela Giménez; Ignacio Torres; Paula Amat; María José Remigia; Juan Alberola; Nieves Carbonell; José Ferreres; María Luisa Blasco; David Navarro
Journal:  Sci Rep       Date:  2022-08-22       Impact factor: 4.996

Review 6.  Frontline workers: Mediators of mucosal immunity in community acquired pneumonia and COVID-19.

Authors:  Priyanka S Hastak; Christopher R Andersen; Anthony D Kelleher; Sarah C Sasson
Journal:  Front Immunol       Date:  2022-09-23       Impact factor: 8.786

Review 7.  COVID-19 immunopathology: From acute diseases to chronic sequelae.

Authors:  Mohd Arish; Wei Qian; Harish Narasimhan; Jie Sun
Journal:  J Med Virol       Date:  2022-09-03       Impact factor: 20.693

8.  Heterogenous CD8+ T Cell Maturation and 'Polarization' in Acute and Convalescent COVID-19 Patients.

Authors:  Igor V Kudryavtsev; Natalia A Arsentieva; Zoia R Korobova; Dmitry V Isakov; Artem A Rubinstein; Oleg K Batsunov; Irina V Khamitova; Raisa N Kuznetsova; Tikhon V Savin; Tatiana V Akisheva; Oksana V Stanevich; Aleksandra A Lebedeva; Evgeny A Vorobyov; Snejana V Vorobyova; Alexander N Kulikov; Maria A Sharapova; Dmitrii E Pevtsov; Areg A Totolian
Journal:  Viruses       Date:  2022-08-28       Impact factor: 5.818

9.  Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19.

Authors:  Julie C Wilson; David Kealy; Sally R James; Tobias Plowman; Katherine Newling; Christopher Jagger; Kara Filbey; Elizabeth R Mann; Joanne E Konkel; Madhvi Menon; Sean B Knight; Angela Simpson; Aliya Prihartadi; Greg Forshaw; Neil Todd; David R A Yates; John R Grainger; Tracy Hussell; Paul M Kaye; Nathalie Signoret; Dimitris Lagos
Journal:  iScience       Date:  2021-12-20
  9 in total

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