Literature DB >> 33768082

Hypercalcaemia: An Extremely Rare Presentation of Hepatosplenic T-Cell Lymphoma.

Sara Almeida Ramalho1, Francisca Abecasis1, Letícia Santos1, Vanessa Leite1, Diogo Gonçalves2, Inês Pintassilgo1, Ana Luisa Broa1.   

Abstract

Hypercalcaemia is a frequent finding in malignancies including lymphomas. However, there are no reports of hypercalcaemia in hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare and aggressive neoplasm which is usually difficult to diagnose. We present a case of HSTCL in which hypercalcaemia was the initial presentation. LEARNING POINTS: Hepatosplenic T-cell lymphoma (HSTCL) is difficult to diagnose, has a poor prognosis and usually presents with hepatosplenomegaly, B symptoms and cytopenias.Hypercalcaemia is an extremely rare clinical presentation of HSTCL.Severe hypercalcaemia is a life-threatening condition and should always be corrected and investigated. © EFIM 2021.

Entities:  

Keywords:  B symptoms; Hypercalcaemia; bone marrow; hepatosplenic lymphoma; hepatosplenomegaly

Year:  2021        PMID: 33768082      PMCID: PMC7977046          DOI: 10.12890/2021_002360

Source DB:  PubMed          Journal:  Eur J Case Rep Intern Med        ISSN: 2284-2594


  5 in total

Review 1.  Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990.

Authors:  E Weidmann
Journal:  Leukemia       Date:  2000-06       Impact factor: 11.528

2.  Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment.

Authors:  G S Falchook; F Vega; N H Dang; F Samaniego; M A Rodriguez; R E Champlin; C Hosing; S Verstovsek; B Pro
Journal:  Ann Oncol       Date:  2009-02-23       Impact factor: 32.976

Review 3.  Hepatosplenic T-cell Lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors.

Authors:  Mariko Yabe; Roberto N Miranda; L Jeffrey Medeiros
Journal:  Hum Pathol       Date:  2018-01-11       Impact factor: 3.466

Review 4.  Diagnosis, Pathophysiology and Management of Hypercalcemia in Malignancy: A Review of the Literature.

Authors:  Nikolaos Asonitis; Anna Angelousi; Christos Zafeiris; George I Lambrou; Ismene Dontas; Eva Kassi
Journal:  Horm Metab Res       Date:  2019-12-11       Impact factor: 2.936

5.  Hepatosplenic and other gammadelta T-cell lymphomas.

Authors:  Francisco Vega; L Jeffrey Medeiros; Philippe Gaulard
Journal:  Am J Clin Pathol       Date:  2007-06       Impact factor: 2.493

  5 in total

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