Four-dimensional digital subtraction angiography for exploration of intraosseous arteriovenous fistula in the sphenoid bone.

BACKGROUND: Intraosseous arteriovenous fistula (AVF) is a rare clinical entity that typically presents with symptoms from their effect on surrounding structures. Here, we report a case of intraosseous AVF in the sphenoid bone that presented with bilateral abducens palsy. CASE DESCRIPTION: A previously healthy man presented with tinnitus for 1 month, and initial imaging suspected dural AVF of the cavernous sinus. Four-dimensional digital subtraction angiography (4D-DSA) imaging and a three-dimensional (3D) fused image from the bilateral external carotid arteries revealed that the shunt was in a large venous pouch within the sphenoid bone that was treated through transvenous coil embolization. His symptoms improved the day after surgery.
CONCLUSION: This is a case presentation of intraosseous AVF in the sphenoid bone and highlights the importance of 4D-DSA and 3D fused images for planning the treatment strategy. Copyright:

INTRODUCTION

Arteriovenous fistulas (AVFs) in the cavernous sinus (CS) are often caused by venous pouches in various locations. Recently, intraosseous shunts have been reported to be the cause of AVF. We report a case of an AVF with an intraosseous shunt in the sphenoid bone, in which preoperative four-dimensional digital subtraction angiography (4D-DSA) and three-dimensional (3D) fused images were a useful treatment modality.

CASE PRESENTATION

A patient presented with tinnitus for 1 month and was referred to an ophthalmology clinic with a complaint of diplopia 7 days prior. Bilateral abducens nerve palsy was diagnosed on examination. Brain magnetic resonance imaging (MRI) showed an abnormal high intensity lesion within the sphenoid bone connected to the bilateral CS. This suggested a CS dural AVF (DAVF).

Cerebral angiography revealed an AVF with a shunt from the right external carotid artery (ECA) and the left ECA in the CS. The bilateral internal maxillary artery (IMA), accessory middle meningeal arteries, deep temporal arteries, and left ascending pharyngeal artery are the feeding arteries from the bilateral ECAs. The shunt flow was from the right ECA branches draining into the venous pouch and into the bilateral CS, then to the bilateral inferior petrosal sinus (IPS). Bilateral CS is the drainage route, which drains into the right superficial middle cerebral vein and intradurally to the right basal vein. Some of the venous drainage refluxed into the superior sagittal sinus [Figures 1 and 2]. 4D-DSA imaging showed that the shunt was in a large venous pouch within the sphenoid bone [Figure 3 and Video 1]. The 3D fused image from bilateral ECAs (right ECA, orange; left ECA, pink) showed that the shunt point was in the sphenoid bone involving the inter CS [Figure 4]. These findings confirmed the presence of a large intraosseous AVF in the sphenoid bone.

Figure 1:

Conventional angiograms from the right external carotid artery (ECA) (a,b,c) and the left ECA (d,e,f) showing a cavernous sinus arteriovenous fistula. The shunt flow from the bilateral ECA branches drain into the bilateral cavernous sinus and into the right superficial middle cerebral vein.

Figure 2:

Lateral view of right ECA angiogram showing that feeding artery from branches of internal maxillary artery feed into venous pouch in the sphenoid sinus and drain into the cavernous sinus.The arterial to venous phases are shown in order from a to c.

Figure 3:

Time series of four-dimensional digital subtraction angiography. Injection of the right external carotid artery shows early filling of the venous pouch in the sphenoid bone draining into the bilateral cavernous sinus.

Figure 4:

Slab maximum intensity projection images (axial (a), sagittal (b), and coronal (c) views) of the right external carotid artery (ECA) angiogram revealed that the arteriovenous fistula was in the sphenoid bone. The three-dimensional fused image from bilateral ECAs (right ECA, orange; left ECA, pink) also showing that the venous pouch was fed by bilateral ECAs. The three-dimensional (3D) fused image from bilateral ECAs (right ECA, orange; left ECA, pink) also showing that the venous pouch was fed by bilateral ECAs (d).

Dynamic visualization of the four-dimensional digital subtraction angiography of the right external carotid artery.

4D-DSA

The images were acquired using commercially available biplane angiography systems equipped with 1920 × 2480 cesium iodide-amorphous silicon flat panel detectors covering an area of approximately 30 × 40 cm (Artis Q biplane and Artis Zee biplane; Siemens Healthcare GmbH, Forchheim, Germany). The patients underwent cerebral angiography using standard techniques. During 4D-DSA image acquisition, two rotational angiography scans were performed; a native mask run followed by a contrast-enhanced fill run with the injection of undiluted contrast medium (Iohexol 300 mg/mL, IOPAQUE; Fuji Pharma Co., Ltd., Tokyo, Japan). The protocol acquired 304 projections over a 260° rotation in 12 s. A power injector was used to inject contrast medium from a guiding catheter placed in the target artery. Undiluted contrast medium was injected with an injection rate of 3.0 mL/s with no X-ray delay, and the injection time was 7 s for 12 s 4D-DSA. Datasets were transferred to a workstation (syngo X- Workplace, Siemens Healthcare GmbH, Forchheim, Germany) for post processing where 4D-DSA images were created and appropriate Volume rendering present was selected for optimal visualization of the vasculature. To better visualize the vasculature relative to the bony structure, fusion images of 4D-DSA and 3D images of the skull from the mask run were generated by the workstation’s application (syngo Dual Volume, Siemens Health- care GmbH, Forchheim, Germany). The radiation dose was extracted from the dose reports automatically generated by the angiography systems and the volume of contrast medium used for 12 s 4D-DSA was retrieved from the medical records of the patients.

Treatment

Under general anesthesia, transvenous coil embolization of the DAVF was performed. A 6-French guiding catheter was navigated to the right internal jugular vein and a 5-French diagnostic catheter was placed into the left ascending pharyngeal artery. A 3.2-F intermediate catheter (TACTICS; Technocrat Corporation, Aichi, Japan) was used for supporting the microcatheter (SL10; Stryker, Kalamazoo, MI). The microcatheter with micro-guidewire (CHIKAI 0.014 inch Asahi Intecc) was advanced into the right CS through the right IPS. To confirm the location of the tip of the microcatheter, C-arm cone-beam computed tomography equipment (Artis Q biplane and Artis Q biplane; Siemens Healthcare GmbH, Forchheim, Germany) images were taken while the microcatheter was filled with contrast medium. A microcatheter in the venous sac was identified by a fusion of that image and a 3D DSA image of the left ECA [Figure 5]. After performing framing with Target XL 360 coil (6 mm × 30 cm) (Stryker, Kalamazoo, MI), venous sac embolization was performed with a total of 11 platinum coils (iED coil; Kaneka Medics, Osaka, Japan).

Figure 5:

Transvenous approach with positioning of the microcatheter into the venous pouch. A microcatheter in the venous sac was identified by digital subtraction angiography (DSA) road map image (a and d), Dyna computed tomography (CT) image (b and e) and fusion images Dyna CT and three-dimensional-DSA image of the left external carotid artery (c and f).

Outcome and follow-up

Bilateral ECA angiogram showed that the shunt had disappeared [Figure 6]. The diplopia and eye movement limitation improved the day after surgery. Three months after the procedure, the patient’s symptoms remained unremarkable, and no recurrent findings were noted on MRI.

Figure 6:

Postembolization: frontal (a) and lateral (b) angiograms show complete cessation of venous pouch by bare platinum coils. An AP view of the bilateral external carotid artery (c and d) angiogram after embolization revealed the disappearance of the arteriovenous fistula.

DISCUSSION

We report a case of intraosseous CS AVF in which the venous pouch was in the sphenoid bone. The most frequent location of the shunted pouch is the posterior part of CS.[7] However, 2.85% of cases diagnosed with CS AVF were reported to have mimicked the cavernous AVF,[8] and these shunts were located in the intraosseous venous pouch rather than in the dural surface. The presence of intraosseous shunts in AVF of CS is reported to be 24–33%[3,5] with a high prevalence in the dorsum sellae and condyle.[5] Among these, intraosseous AVF of the sphenoid bone is a rare clinical entity.[9,10]

4D-DSA and 3D-DSA fusion images were useful in planning therapeutic strategies.

4D-DSA is a new imaging algorithm that provides time-resolved 3D DSA through a single acquisition in the AngioSuite.[6] This imaging technique consists of 4D acquisition that allows 3D volume reconstruction at different temporal phases of the acquisition. It may help to overcome the problem of vessel overlap and thus may improve the capacity to distinguish arterial feeders from draining veins or nodal compartments in complex vascular malformations.[1]

3D-DSA fusion images are also a useful imaging technique for treatment planning in intracranial vascular diseases involving multiple vessels.[2] Fusion imaging revealed identical venous sac shunts from the bilateral ECAs, allowing for appropriate microcatheter guidance and coil embolization. In cases of vascular malformations and AVF involving multiple vessels, the use of imaging information such as 4D-DSA and 3D-DSA can reduce treatment time and radiation exposure.

Transvenous endovascular approaches have been described to treat intraosseous AVF.[10] In this case, the decision of taking the transvenous approach was because of the convergence of multiple feeders from different arteries into the venous sac. In the present case, obliteration of AVF was achieved with minimal use of a long and wide coil (ED coil ∞; Kaneka Medics, Osaka, Japan). Although some cases of transarterial embolization with liquid embolic material have been reported,[4] we believe that detachable platinum coils are safer than transarterial liquid embolic agents and are more reliable due to the lack of risk of complications from dangerous anastomosis.

CONCLUSION

This is a case presentation of intraosseous AVF in the sphenoid bone and highlights the importance of 4D-DSA and 3D fused images for planning the treatment strategy.