| Literature DB >> 33767590 |
Wen Xie1,2, Hecheng Zhu1,3, Ming Zhao3, Lei Wang1,2, Shasha Li1,2, Cong Zhao1,2, Yao Zhou1,2, Bin Zhu1,2, Xingjun Jiang1,4, Weidong Liu1,2, Caiping Ren1,2.
Abstract
The self-renewal, pluripotency and differentiation of stem cells are regulated by various genetic and epigenetic factors. As a kind of RNA binding protein (RBP), the heterogeneous nuclear ribonucleoproteins (hnRNPs) can act as "RNA scaffold" and recruit mRNA, lncRNA, microRNA and circRNA to affect mRNA splicing and processing, regulate gene transcription and post-transcriptional translation, change genome structure, and ultimately play crucial roles in the biological processes of cells. Recent researches have demonstrated that hnRNPs are irreplaceable for self-renewal and differentiation of stem cells. hnRNPs function in stem cells by multiple mechanisms, which include regulating mRNA stability, inducing alternative splicing of mRNA, epigenetically regulate gene expression, and maintaining telomerase activity and telomere length. The functions and the underlying mechanisms of hnRNPs in stem cells deserve further investigation. © The author(s).Entities:
Keywords: Epigenetic regulation; Heterogeneous nuclear ribonucleoprotein; Stem cell; Telomere length and telomerase activity; mRNA stability
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Year: 2021 PMID： 33767590 PMCID： PMC7975692 DOI： 10.7150/ijbs.55120
Source DB: PubMed Journal: Int J Biol Sci ISSN： 1449-2288 Impact factor: 6.580