| Literature DB >> 33767531 |
Yusuke Takahira1, Miao Chen1, Yu Kawamata1, Pavel Mykhailiuk1,2, Hugh Nakamura1, Byron K Peters1, Solomon H Reisberg1, Chao Li1, Longrui Chen3, Tamaki Hoshikawa4, Tomoyuki Shibuguchi4, Phil S Baran1.
Abstract
A simple and robust method for electrochemical alkyl C-H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C-H bonds were converted to their C-F congeners. The scalability of the reaction was also demonstrated with a 100 gram preparation of fluorovaline.Entities:
Keywords: C–H functionalization; electrochemistry; fluorination; organic synthesis; radical
Year: 2019 PMID： 33767531 PMCID： PMC7990259 DOI： 10.1055/s-0037-1611737
Source DB: PubMed Journal: Synlett ISSN： 0936-5214 Impact factor: 2.454