Literature DB >> 33767421

A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming.

Sin Chi Chew1, Si Ying Choo1, Pierce Kah-Hoe Chow2,3,4.   

Abstract

We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF-NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.

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Year:  2021        PMID： 33767421      PMCID： PMC8185081          DOI： 10.1038/s41416-021-01286-0

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  4 in total

1.  CTB-193M12.5 Promotes Hepatocellular Carcinoma Progression via Enhancing NSD1-Mediated WNT10B/Wnt/β-Catenin Signaling Activation.

Authors:  Shuhua Zhang; Mi Jiang; Huan Cao; Jun Xiong; Jianqun Xu
Journal:  J Hepatocell Carcinoma       Date:  2022-06-07

2.  ADORA2A-AS1 Restricts Hepatocellular Carcinoma Progression via Binding HuR and Repressing FSCN1/AKT Axis.

Authors:  Jian Pu; Ya Zhang; Anmin Wang; Zebang Qin; Chenyi Zhuo; Wenchuan Li; Zuoming Xu; Qianli Tang; Jianchu Wang; Huamei Wei
Journal:  Front Oncol       Date:  2021-10-18       Impact factor: 6.244

3.  PLVAP is associated with glioma-associated malignant processes and immunosuppressive cell infiltration as a promising marker for prognosis.

Authors:  Kaiming Ma; Xin Chen; Xiaofang Zhao; Suhua Chen; Jun Yang
Journal:  Heliyon       Date:  2022-08-19

4.  LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1.

Authors:  Yue Li; Chen Chen; Hai-Lin Liu; Zhen-Fa Zhang; Chang-Li Wang
Journal:  Cell Mol Biol Lett       Date:  2022-10-11       Impact factor: 8.702
  4 in total

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