Literature DB >> 33766856

Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop.

Lu Bai1,2, Margaux Vienne3, Ling Tang1,2, Yann Kerdiles3, Rui Sun4,2,5, Eric Vivier6,7,8, Hui Peng4,2,5, Zhigang Tian4,2,5, Marion Etiennot3, Bertrand Escalière3, Justine Galluso3, Haiming Wei1,2,5.   

Abstract

The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin-Sca-1+Mac-1+ hematopoietic stem cells derived from the fetal liver. This population includes Lin-CD122+CD49a+ progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR+ liver progenitors. Thus, an IFN-γ-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2021        PMID： 33766856     DOI： 10.1126/science.aba4177

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions.

Authors:  Yawen Chen; Xianwei Wang; Xiaolei Hao; Bin Li; Wanyin Tao; Shu Zhu; Kun Qu; Haiming Wei; Rui Sun; Hui Peng; Zhigang Tian
Journal:  J Exp Med       Date:  2022-03-29       Impact factor: 14.307

Review 2.  Intravital Imaging of Inflammatory Response in Liver Disease.

Authors:  Yang Wang; Jing Wang
Journal:  Front Cell Dev Biol       Date:  2022-06-28

Review 3.  Natural killer cell homing and trafficking in tissues and tumors: from biology to application.

Authors:  Guang He Ran; Yu Qing Lin; Lei Tian; Tao Zhang; Dong Mei Yan; Jian Hua Yu; You Cai Deng
Journal:  Signal Transduct Target Ther       Date:  2022-06-29

4.  Hobit confers tissue-dependent programs to type 1 innate lymphoid cells.

Authors:  Kentaro Yomogida; Tarin M Bigley; Tihana Trsan; Susan Gilfillan; Marina Cella; Wayne M Yokoyama; Takeshi Egawa; Marco Colonna
Journal:  Proc Natl Acad Sci U S A       Date:  2021-12-14       Impact factor: 12.779

5.  Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.

Authors:  Christin Friedrich; Renske L R E Taggenbrock; Rémi Doucet-Ladevèze; Gosia Golda; Rebekka Moenius; Panagiota Arampatzi; Natasja A M Kragten; Katharina Kreymborg; Mercedes Gomez de Agüero; Wolfgang Kastenmüller; Antoine-Emmanuel Saliba; Dominic Grün; Klaas P J M van Gisbergen; Georg Gasteiger
Journal:  Nat Immunol       Date:  2021-08-30       Impact factor: 25.606

Review 6.  Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives.

Authors:  Nicolas Jacquelot; Cyril Seillet; Fernando Souza-Fonseca-Guimaraes; Adrian G Sacher; Gabrielle T Belz; Pamela S Ohashi
Journal:  Int J Mol Sci       Date:  2021-08-22       Impact factor: 5.923

Review 7.  Antiviral Activities of Group I Innate Lymphoid Cells.

Authors:  Ramon A Lujan; Sophia M Vrba; Heather D Hickman
Journal:  J Mol Biol       Date:  2021-09-22       Impact factor: 5.469

Review 8.  The role of natural killer cells in liver inflammation.

Authors:  A J Highton; I S Schuster; M A Degli-Esposti; M Altfeld
Journal:  Semin Immunopathol       Date:  2021-07-07       Impact factor: 9.623

9.  Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver.

Authors:  Chiara Di Censo; Marie Marotel; Irene Mattiola; Lena Müller; Gianluca Scarno; Giuseppe Pietropaolo; Giovanna Peruzzi; Mattia Laffranchi; Julija Mazej; Mohamed Shaad Hasim; Sara Asif; Eleonora Russo; Luana Tomaipitinca; Helena Stabile; Seung-Hwan Lee; Laura Vian; Massimo Gadina; Angela Gismondi; Han-Yu Shih; Yohei Mikami; Cristina Capuano; Giovanni Bernardini; Michael Bonelli; Silvano Sozzani; Andreas Diefenbach; Michele Ardolino; Angela Santoni; Giuseppe Sciumè
Journal:  Eur J Immunol       Date:  2021-08-19       Impact factor: 6.688

10.  Local tissue development of type 1 innate lymphoid cells: guided by interferon-gamma.

Authors:  Thomas M Conlon; Percy A Knolle; Ali Önder Yildirim
Journal:  Signal Transduct Target Ther       Date:  2021-07-29
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