| Literature DB >> 33766848 |
Hongbing Yang1, Margarida Rei2, Simon Brackenridge1, Elena Brenna1, Hong Sun1,3,4, Shaheed Abdulhaqq5, Michael K P Liu6, Weiwei Ma6, Prathiba Kurupati2, Xiaoning Xu6, Vincenzo Cerundolo2, Edward Jenkins2, Simon J Davis2, Jonah B Sacha5, Klaus Früh5, Louis J Picker5, Persephone Borrow1, Geraldine M Gillespie1, Andrew J McMichael7.
Abstract
Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infected individuals. Here, HLA-E-restricted, HIV-1-specific CD8 + T cells were primed in vitro. These T cell clones and allogeneic CD8 + T cells transduced with their T cell receptors suppressed HIV-1 replication in CD4 + T cells in vitro. Vaccine induction of efficacious HLA-E-restricted HIV-1-specific T cells should therefore be possible.Entities:
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Year: 2021 PMID： 33766848 PMCID： PMC8258078 DOI： 10.1126/sciimmunol.abg1703
Source DB: PubMed Journal: Sci Immunol ISSN： 2470-9468