Literature DB >> 33766812

Therapeutic Escape in Gαq-mutant Uveal Melanoma: It's a FAK.

J William Harbour1.   

Abstract

Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gαq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.See related article by Paradis et al., p. 3190. ©2021 American Association for Cancer Research.

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Year:  2021        PMID： 33766812      PMCID： PMC8172474          DOI： 10.1158/1078-0432.CCR-21-0567

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  5 in total

1.  HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma.

Authors:  Fernanda Faião-Flores; Michael F Emmons; Michael A Durante; Fumi Kinose; Biswarup Saha; Bin Fang; John M Koomen; Srikumar P Chellappan; Silvya Stuchi Maria-Engler; Uwe Rix; Jonathan D Licht; J William Harbour; Keiran S M Smalley
Journal:  Clin Cancer Res       Date:  2019-06-21       Impact factor: 12.531

2.  Frequent mutation of BAP1 in metastasizing uveal melanomas.

Authors:  J William Harbour; Michael D Onken; Elisha D O Roberson; Shenghui Duan; Li Cao; Lori A Worley; M Laurin Council; Katie A Matatall; Cynthia Helms; Anne M Bowcock
Journal:  Science       Date:  2010-11-04       Impact factor: 47.728

Review 3.  Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.

Authors:  Vivian Chua; Dominic Lapadula; Clinita Randolph; Jeffrey L Benovic; Philip B Wedegaertner; Andrew E Aplin
Journal:  Mol Cancer Res       Date:  2017-02-21       Impact factor: 5.852

4.  Punctuated evolution of canonical genomic aberrations in uveal melanoma.

Authors:  Matthew G Field; Michael A Durante; Hima Anbunathan; Louis Z Cai; Christina L Decatur; Anne M Bowcock; Stefan Kurtenbach; J William Harbour
Journal:  Nat Commun       Date:  2018-01-09       Impact factor: 14.919

5.  Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.

Authors:  Justine S Paradis; Monica Acosta; Robert Saddawi-Konefka; Ayush Kishore; Frederico Gomes; Nadia Arang; Manoela Tiago; Silvia Coma; Simone Lubrano; Xingyu Wu; Kyle Ford; Chi-Ping Day; Glenn Merlino; Prashant Mali; Jonathan A Pachter; Takami Sato; Andrew E Aplin; J Silvio Gutkind
Journal:  Clin Cancer Res       Date:  2021-02-10       Impact factor: 12.531
  5 in total
  1 in total

1.  Low Level of PALMD Contributes to the Metastasis of Uveal Melanoma.

Authors:  Min-Yun Cai; Yue-Li Xu; Hua Rong; Hai Yang
Journal:  Front Oncol       Date:  2022-04-13       Impact factor: 5.738
  1 in total

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