Victor Yuji Yariwake1, Janaína Iannicelli Torres2, Amandda Rakell Peixoto Dos Santos3, Sarah Cristina Ferreira Freitas4, Kátia De Angelis4, Sylvia Costa Lima Farhat2,5, Niels Olsen Saraiva Câmara3,6, Mariana Matera Veras2. 1. Laboratory of Experimental Air Pollution, Department of Pathology, School of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455 - 1st floor (room 1220), São Paulo, SP, 01246-903, Brazil. victor.yariwake@usp.br. 2. Laboratory of Experimental Air Pollution, Department of Pathology, School of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455 - 1st floor (room 1220), São Paulo, SP, 01246-903, Brazil. 3. Laboratory of Experimental Cellular Immunology, Department of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil. 4. Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil. 5. Pediatric Rheumatology Unit, Children's Institute of Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil. 6. Laboratory of Transplant Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Abstract
BACKGROUND: Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. RESULTS: Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. CONCLUSIONS: This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.
BACKGROUND: Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. RESULTS:Female NZBWmice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBWmice exposed to FA. CONCLUSIONS: This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.
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