Literature DB >> 33765397

Reduced membrane cholesterol content in skeletal muscle is not essential for greater insulin-stimulated glucose uptake after acute exercise by rats.

Haiyan Wang1,1, Edward B Arias1,1, Gregory D Cartee1,1.   

Abstract

One exercise session can elevate insulin-stimulated glucose uptake (GU) by skeletal muscle, but it is uncertain if this effect is accompanied by altered membrane cholesterol content, which is reportedly inversely related to insulin-stimulated GU. Muscles from sedentary (SED) or exercised 3 h post-exercise (3hPEX) rats were evaluated for GU, membrane cholesterol, and phosphorylation of cholesterol regulatory proteins (pHMCGRSer872 and pABCA1Ser2054). Insulin-stimulated GU for 3hPEX exceeded SED. Membrane cholesterol, pHMCGRSer872 and pABCA1Ser2054 did not differ between groups. Novelty: Alterations in membrane cholesterol and phosphorylation of proteins that regulate muscle cholesterol are not essential for elevated insulin-stimulated GU in skeletal muscle after acute exercise.

Entities:  

Keywords:  captation de glucose; cholestérol membranaire; exercice; exercise; glucose uptake; membrane cholesterol

Mesh：

Substances：

Year:  2021        PMID： 33765397      PMCID： PMC9359348          DOI： 10.1139/apnm-2021-0130

Source DB:  PubMed          Journal:  Appl Physiol Nutr Metab        ISSN： 1715-5312            Impact factor:   3.016


  26 in total

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Journal:  Am J Physiol Endocrinol Metab       Date:  2019-06-25       Impact factor: 4.310

2.  The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization.

Authors:  R A DeFronzo; E Jacot; E Jequier; E Maeder; J Wahren; J P Felber
Journal:  Diabetes       Date:  1981-12       Impact factor: 9.461

3.  Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.

Authors:  Jonathan S Fisher; Jiaping Gao; Dong-Ho Han; John O Holloszy; Lorraine A Nolte
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-01       Impact factor: 4.310

4.  Growth hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats.

Authors:  G D Cartee; E E Bohn
Journal:  Am J Physiol       Date:  1995-05

5.  Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.

Authors:  R Sato; J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

6.  Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice.

Authors:  Pablo Sánchez-Aguilera; Alexis Diaz-Vegas; Cristián Campos; Oscar Quinteros-Waltemath; Hugo Cerda-Kohler; Genaro Barrientos; Ariel Contreras-Ferrat; Paola Llanos
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2018-09-19       Impact factor: 4.698

7.  Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.

Authors:  Shuai Chen; David H Wasserman; Carol MacKintosh; Kei Sakamoto
Journal:  Cell Metab       Date:  2011-01-05       Impact factor: 27.287

8.  Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.

Authors:  K M Habegger; B A Penque; W Sealls; L Tackett; L N Bell; E K Blue; P J Gallagher; M Sturek; M A Alloosh; H O Steinberg; R V Considine; J S Elmendorf
Journal:  Diabetologia       Date:  2011-10-15       Impact factor: 10.122

9.  Exercise training prevents skeletal muscle plasma membrane cholesterol accumulation, cortical actin filament loss, and insulin resistance in C57BL/6J mice fed a western-style high-fat diet.

Authors:  Ashley G Ambery; Lixuan Tackett; Brent A Penque; Joseph T Brozinick; Jeffrey S Elmendorf
Journal:  Physiol Rep       Date:  2017-08

10.  Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

Authors:  P R Clarke; D G Hardie
Journal:  EMBO J       Date:  1990-08       Impact factor: 11.598
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  1 in total

1.  Exercise effects on γ3-AMPK activity, Akt substrate of 160 kDa phosphorylation, and glucose uptake in muscle of normal and insulin-resistant female rats.

Authors:  Haiyan Wang; Edward B Arias; Jonas T Treebak; Gregory D Cartee
Journal:  J Appl Physiol (1985)       Date:  2021-12-09
  1 in total

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