Literature DB >> 33764978

Priapism following a juvenile Russell's viper bite: An unusual case report.

Subramanian Senthilkumaran1, Harry F Williams2, Ketan Patel3, Steven A Trim4, Ponniah Thirumalaikolundusubramanian5, Sakthivel Vaiyapuri6.   

Abstract

Following a bite from a juvenile Russell's viper (Daboia russelii), a priapism (painful erection) developed rapidly in a 16-year-old male and only subsided after administration of antivenom 3 hours later. Potential mechanisms for this snakebite-induced priapism are unclear but likely due to venom toxins causing nitric oxide (NO) release and subsequent vasodilation of endothelium in the corpus cavernosum, although the possible involvement of other mechanisms cannot be ruled out. We strongly believe that this unusual case report may lead to further scientific research in order to improve the clinical understanding of the pathophysiology of envenomation due to Russell's viper bites. Although it is too early to speculate, further research may also discover the possibilities of developing venom-based candidate molecules to treat sexual dysfunction in males and females.

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Year:  2021        PMID: 33764978      PMCID: PMC7993604          DOI: 10.1371/journal.pntd.0009242

Source DB:  PubMed          Journal:  PLoS Negl Trop Dis        ISSN: 1935-2727


  37 in total

1.  Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.

Authors:  Kenia P Nunes; Marta N Cordeiro; Michael Richardson; Marcia N Borges; Simone O F Diniz; Valbert N Cardoso; Rita Tostes; Maria Elena De Lima; Robert Clinton Webb; Romulo Leite
Journal:  J Sex Med       Date:  2010-08-16       Impact factor: 3.802

Review 2.  The pharmacology of voltage-gated sodium channel activators.

Authors:  Jennifer R Deuis; Alexander Mueller; Mathilde R Israel; Irina Vetter
Journal:  Neuropharmacology       Date:  2017-04-14       Impact factor: 5.250

3.  Perianesthetic development of diaphragmatic hernia in a horse with equine pituitary pars intermedia dysfunction (PPID).

Authors:  Molly K Shepard; Wesley L Lee; Randy B Eggleston
Journal:  Can Vet J       Date:  2015-01       Impact factor: 1.008

Review 4.  New insights on arthropod toxins that potentiate erectile function.

Authors:  Kenia P Nunes; Fernanda S Torres; Marcia H Borges; Alessandra Matavel; Adriano M C Pimenta; Maria E De Lima
Journal:  Toxicon       Date:  2013-04-10       Impact factor: 3.033

5.  PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP.

Authors:  Carolina Nunes Silva; Kenia Pedrosa Nunes; Fernanda Silva Torres; Juliana Silva Cassoli; Daniel Moreira Santos; Flávia De Marco Almeida; Alessandra Matavel; Jader Santos Cruz; Arthur Santos-Miranda; Allancer Divino C Nunes; Carlos Henrique Castro; Ricardo Andrés Machado de Ávila; Carlos Chávez-Olórtegui; Stephanie Stransky Láuar; Liza Felicori; Jarbas Magalhães Resende; Elizabeth Ribeiro da Silva Camargos; Márcia Helena Borges; Marta Nascimento Cordeiro; Steve Peigneur; Jan Tytgat; Maria Elena de Lima
Journal:  J Urol       Date:  2015-06-26       Impact factor: 7.450

6.  Phoneutria nigriventer spider toxin Tx2-6 causes priapism and death: a histopathological investigation in mice.

Authors:  Kátia R M Leite; Enrico Andrade; Adriana T Ramos; Fabio C Magnoli; Miguel Srougi; Lanfranco R P Troncone
Journal:  Toxicon       Date:  2012-06-26       Impact factor: 3.033

Review 7.  Defibrinogenating enzymes.

Authors:  W R Bell
Journal:  Drugs       Date:  1997       Impact factor: 9.546

Review 8.  Endothelial nitric oxide synthase regulation in female genital tract structures.

Authors:  Biljana Musicki; Tongyun Liu; Gwen A Lagoda; Trinity J Bivalacqua; Travis D Strong; Arthur L Burnett
Journal:  J Sex Med       Date:  2008-12-05       Impact factor: 3.802

9.  Priapism associated with pregabalin.

Authors:  Ali A Alsulihem; Danny M Rabah
Journal:  Urol Ann       Date:  2014-10

10.  D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.

Authors:  Rahini Kakumanu; Sanjaya Kuruppu; Lachlan D Rash; Geoffrey K Isbister; Wayne C Hodgson; Barbara K Kemp-Harper
Journal:  Toxins (Basel)       Date:  2019-04-01       Impact factor: 4.546

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  1 in total

1.  Ultrasound-Guided Compression Method Effectively Counteracts Russell's Viper Bite-Induced Pseudoaneurysm.

Authors:  Subramanian Senthilkumaran; Stephen W Miller; Harry F Williams; Rajendran Vaiyapuri; Ravi Savania; Namasivayam Elangovan; Ponniah Thirumalaikolundusubramanian; Ketan Patel; Sakthivel Vaiyapuri
Journal:  Toxins (Basel)       Date:  2022-04-06       Impact factor: 5.075

  1 in total

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