Literature DB >> 33764452

Cytoplasmic HYL1 modulates miRNA-mediated translational repression.

Xi Yang1,2, Weiguo Dong1,2,3, Wenqing Ren1,2, Qiuxia Zhao1, Feijie Wu1, Yuke He1.   

Abstract

MicroRNAs (miRNAs) control various biological processes by repressing target mRNAs. In plants, miRNAs mediate target gene repression via both mRNA cleavage and translational repression. However, the mechanism underlying this translational repression is poorly understood. Here, we found that Arabidopsis thaliana HYPONASTIC LEAVES1 (HYL1), a core component of the miRNA processing machinery, regulates miRNA-mediated mRNA translation but not miRNA biogenesis when it localized in the cytoplasm. Cytoplasmic HYL1 localizes to the endoplasmic reticulum and associates with ARGONAUTE1 (AGO1) and ALTERED MERISTEM PROGRAM1. In the cytoplasm, HYL1 monitors the distribution of AGO1 onto polysomes, binds to the mRNAs of target genes, represses their translation, and partially rescues the phenotype of the hyl1 null mutant. This study uncovered another function of HYL1 and provides insight into the mechanism of plant gene regulation. © American Society of Plant Biologists 2021. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Year:  2021        PMID： 33764452      PMCID： PMC8290291          DOI： 10.1093/plcell/koab090

Source DB:  PubMed          Journal:  Plant Cell        ISSN： 1040-4651            Impact factor:   11.277


  91 in total

1.  A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants.

Authors:  Brook K Nelson; Xue Cai; Andreas Nebenführ
Journal:  Plant J       Date:  2007-07-30       Impact factor: 6.417

2.  Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs.

Authors:  N Baumberger; D C Baulcombe
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-04       Impact factor: 11.205

3.  SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis.

Authors:  Li Yang; Ziqiang Liu; Feng Lu; Aiwu Dong; Hai Huang
Journal:  Plant J       Date:  2006-08-02       Impact factor: 6.417

4.  Mutations in the GW-repeat protein SUO reveal a developmental function for microRNA-mediated translational repression in Arabidopsis.

Authors:  Li Yang; Gang Wu; R Scott Poethig
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-19       Impact factor: 11.205

5.  A short amino acid sequence able to specify nuclear location.

Authors:  D Kalderon; B L Roberts; W D Richardson; A E Smith
Journal:  Cell       Date:  1984-12       Impact factor: 41.582

6.  The Protein Phosphatase 4 and SMEK1 Complex Dephosphorylates HYL1 to Promote miRNA Biogenesis by Antagonizing the MAPK Cascade in Arabidopsis.

Authors:  Chuanbin Su; Ziwei Li; Jinping Cheng; Lei Li; Songxiao Zhong; Li Liu; Yun Zheng; Binglian Zheng
Journal:  Dev Cell       Date:  2017-06-05       Impact factor: 12.270

7.  Comprehensive protein-based artificial microRNA screens for effective gene silencing in plants.

Authors:  Jian-Feng Li; Hoo Sun Chung; Yajie Niu; Jenifer Bush; Matthew McCormack; Jen Sheen
Journal:  Plant Cell       Date:  2013-05-03       Impact factor: 11.277

8.  HYL1 controls the miR156-mediated juvenile phase of vegetative growth.

Authors:  Shuxia Li; Xi Yang; Feijie Wu; Yuke He
Journal:  J Exp Bot       Date:  2012-01-20       Impact factor: 6.992

9.  SKI2 mediates degradation of RISC 5'-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis.

Authors:  Anja Branscheid; Antonin Marchais; Gregory Schott; Heike Lange; Dominique Gagliardi; Stig Uggerhøj Andersen; Olivier Voinnet; Peter Brodersen
Journal:  Nucleic Acids Res       Date:  2015-10-12       Impact factor: 16.971

10.  A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.

Authors:  Xuemei Chen
Journal:  Science       Date:  2003-07-31       Impact factor: 47.728
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  8 in total

1.  Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis.

Authors:  Lusheng Fan; Bin Gao; Ye Xu; Nora Flynn; Brandon Le; Chenjiang You; Shaofang Li; Natalia Achkar; Pablo A Manavella; Zhenbiao Yang; Xuemei Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2022-10-03       Impact factor: 12.779

2.  From the archives: complexity of posttranscriptional control; miRNA, polyadenylation, and splicing.

Authors:  Ching Chan
Journal:  Plant Cell       Date:  2022-05-24       Impact factor: 12.085

3.  Osa-miR1320 targets the ERF transcription factor OsERF096 to regulate cold tolerance via JA-mediated signaling.

Authors:  Mingzhe Sun; Yang Shen; Yue Chen; Yan Wang; Xiaoxi Cai; Junkai Yang; Bowei Jia; Weifeng Dong; Xi Chen; Xiaoli Sun
Journal:  Plant Physiol       Date:  2022-08-01       Impact factor: 8.005

4.  Biogenesis, Trafficking, and Function of Small RNAs in Plants.

Authors:  Yunjia Tang; Xiaoning Yan; Chenxian Gu; Xiaofeng Yuan
Journal:  Front Plant Sci       Date:  2022-02-17       Impact factor: 5.753

5.  Dynamic Phosphorylation of miRNA Biogenesis Factor HYL1 by MPK3 Involving Nuclear-Cytoplasmic Shuttling and Protein Stability in Arabidopsis.

Authors:  Prakash Kumar Bhagat; Deepanjali Verma; Kirti Singh; Raghuram Badmi; Deepika Sharma; Alok Krishna Sinha
Journal:  Int J Mol Sci       Date:  2022-03-30       Impact factor: 5.923

6.  DRB2 Modulates Leaf Rolling by Regulating Accumulation of MicroRNAs Related to Leaf Development in Rice.

Authors:  Zhaodi Yuan; Jihong Pan; Congping Chen; Yulin Tang; Hongshan Zhang; Jia Guo; Xiaorong Yang; Longfei Chen; Chunyan Li; Ke Zhao; Qian Wang; Bin Yang; Changhui Sun; Xiaojian Deng; Pingrong Wang
Journal:  Int J Mol Sci       Date:  2022-09-22       Impact factor: 6.208

7.  An integrated transcriptome and metabolome approach reveals the accumulation of taste-related metabolites and gene regulatory networks during watermelon fruit development.

Authors:  Chengsheng Gong; Hongju Zhu; Xuqiang Lu; Dongdong Yang; Shengjie Zhao; Muhammad Jawad Umer; Nan He; Pingli Yuan; Muhammad Anees; Weinan Diao; M O Kaseb; Wenge Liu
Journal:  Planta       Date:  2021-07-22       Impact factor: 4.116

Review 8.  Catalytic activities, molecular connections, and biological functions of plant RNA exosome complexes.

Authors:  Heike Lange; Dominique Gagliardi
Journal:  Plant Cell       Date:  2022-03-04       Impact factor: 11.277
  8 in total

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