Rohit Aiyer1, Selaiman Noori2, Frank Schirripa3, Michael Schirripa4, Talal Aboud5, Sameer Jain6, Amitabh Gulati7, Vinay Puttanniah7, Semih Gungor8, Corey Hunter9. 1. Department of Anesthesiology, Pain Management & Perioperative Medicine- Henry Ford Health System, Detroit, MI, USA. 2. Lakeside Spine & Pain, Lake Havasu City, AZ, USA. 3. Department of Rehabilitation & Regenerative Medicine, NewYork-Presbyterian Hospital/Weill Cornell Medicine & Columbia Campuses, NY, USA. 4. Department of Anesthesiology, NewYork-Presbyterian, Brooklyn Methodist Hospital, Brooklyn, NY, USA. 5. Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA. 6. Pain Centers of America, White Hall, AK, USA. 7. Department of Anesthesia & Critical Care, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, NY, USA. 8. Division of Pain Medicine, Department of Anesthesiology, Hospital for Special Surgery, Weill Cornell Medicine, NY, USA. 9. Ainsworth Institute of Pain Management & Department of Rehabilitation & Human Performance, Mount Sinai Health System, NY, USA.
Abstract
Introduction: Knee osteoarthritis is a degenerative joint disease that is secondary to degradation of articular cartilage, reformation of subchondral bone through degradation and proliferation as well as presence of synovitis. Materials & methods: This systematic review was conducted and reported as per Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: A total of 30 of the 48 comparators showed statistically significant superiority with platelet-rich plasma (PRP) compared with a control, while the other 16 comparators showed no significant difference between PRP and the comparator. Conclusion: We can only recommend PRP for patients with early-stage osteoarthritis (I or II) and who are aged below 65, based on our findings. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) recommendations, while studies reviewed were randomized controlled studies, and therefore, high grade, due to variance in imprecision, risk of bias and inconsistency among the 37 studies, it would be reasonable to rate this paper as subjectively moderate.
Introduction: Knee osteoarthritis is a degenerative joint disease that is secondary to degradation of articular cartilage, reformation of subchondral bone through degradation and proliferation as well as presence of synovitis. Materials & methods: This systematic review was conducted and reported as per Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: A total of 30 of the 48 comparators showed statistically significant superiority with platelet-rich plasma (PRP) compared with a control, while the other 16 comparators showed no significant difference between PRP and the comparator. Conclusion: We can only recommend PRP for patients with early-stage osteoarthritis (I or II) and who are aged below 65, based on our findings. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) recommendations, while studies reviewed were randomized controlled studies, and therefore, high grade, due to variance in imprecision, risk of bias and inconsistency among the 37 studies, it would be reasonable to rate this paper as subjectively moderate.
Authors: Nima Heidari; Mark Slevin; Yasmin Zeinolabediny; Davide Meloni; Stefano Olgiati; Adrian Wilson; Ali Noorani; Leonard Azamfirei Journal: J Clin Med Date: 2022-02-17 Impact factor: 4.241