Matilda J Pitt1, Joan K Morris2. 1. Department of Mathematical Sciences, Durham University, Durham, United Kingdom. 2. Population Health Research Institute, St George's, University of London, London, United Kingdom.
Abstract
OBJECTIVE: To investigate if the survival of children with congenital anomalies has improved from 2000 to 2015 and whether there is heterogeneity in the improvements across Europe. DESIGN: Population-based study of routine collected data from the WHO database on mortality and causes. SETTING: Data on 31 European countries from 2000 to 2015. MAIN OUTCOME MEASURES: All-cause and congenital anomaly mortality rates for infants and children up to age 9 in countries and regions of Europe. RESULTS: The relative odds of all-cause mortality in 2015 compared with 2000 was 0.54 (95% CI: 0.50-0.59) for under 1, 0.48 (95% CI: 0.44-0.53) for ages 1-4, and 0.53 (95% CI: 0.49-0.56) for ages 5-9 with the relative odds of mortality from congenital anomalies being 0.49 (95% CI: 0.44-0.55), 0.51 (95% CI: 0.44-0.60), and 0.65 (95% CI: 0.53-0.80), respectively. The proportion of deaths from congenital anomalies remained relatively constant over time (26, 16, and 9% for under 1, ages 1-4, and ages 5-9, respectively) and was similar in all regions of Europe. For mortality from all causes and from congenital anomalies heterogeneity between countries and regions of Europe was high, with the countries in Eastern Europe having higher rates, but also experiencing greater relative reductions in mortality from 2000 to 2015. CONCLUSION: There was a large geo-spatial disparity in all cause and congenital anomaly mortality for infants and children up to 9. However, all regions saw a significant decrease in all cause and congenital anomaly mortality rates, with the proportions of deaths from congenital anomalies remaining constant over this time.
OBJECTIVE: To investigate if the survival of children with congenital anomalies has improved from 2000 to 2015 and whether there is heterogeneity in the improvements across Europe. DESIGN: Population-based study of routine collected data from the WHO database on mortality and causes. SETTING: Data on 31 European countries from 2000 to 2015. MAIN OUTCOME MEASURES: All-cause and congenital anomaly mortality rates for infants and children up to age 9 in countries and regions of Europe. RESULTS: The relative odds of all-cause mortality in 2015 compared with 2000 was 0.54 (95% CI: 0.50-0.59) for under 1, 0.48 (95% CI: 0.44-0.53) for ages 1-4, and 0.53 (95% CI: 0.49-0.56) for ages 5-9 with the relative odds of mortality from congenital anomalies being 0.49 (95% CI: 0.44-0.55), 0.51 (95% CI: 0.44-0.60), and 0.65 (95% CI: 0.53-0.80), respectively. The proportion of deaths from congenital anomalies remained relatively constant over time (26, 16, and 9% for under 1, ages 1-4, and ages 5-9, respectively) and was similar in all regions of Europe. For mortality from all causes and from congenital anomalies heterogeneity between countries and regions of Europe was high, with the countries in Eastern Europe having higher rates, but also experiencing greater relative reductions in mortality from 2000 to 2015. CONCLUSION: There was a large geo-spatial disparity in all cause and congenital anomaly mortality for infants and children up to 9. However, all regions saw a significant decrease in all cause and congenital anomaly mortality rates, with the proportions of deaths from congenital anomalies remaining constant over this time.
Authors: Alessio Coi; Michele Santoro; Anna Pierini; Judith Rankin; Svetlana V Glinianaia; Joachim Tan; Abigail-Kate Reid; Ester Garne; Maria Loane; Joanne Given; Elisa Ballardini; Clara Cavero-Carbonell; Hermien E K de Walle; Miriam Gatt; Laura García-Villodre; Mika Gissler; Sue Jordan; Sonja Kiuru-Kuhlefelt; Stine Kjaer Urhoj; Kari Klungsøyr; Nathalie Lelong; L Renée Lutke; Amanda J Neville; Makan Rahshenas; Ieuan Scanlon; Diana Wellesley; Joan K Morris Journal: Orphanet J Rare Dis Date: 2022-03-29 Impact factor: 4.123