Patricia Novita Garcia1,2, Wallace Chamon3,4, Norma Allemann3,4. 1. Department of Ophthalmology and Visual Sciences, Federal University of São Paulo-Paulista School of Medicine - UNIFESP-EPM, São Paulo, Brazil. patricianovita@yahoo.com.br. 2. Department of Ophthalmology, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. patricianovita@yahoo.com.br. 3. Department of Ophthalmology and Visual Sciences, Federal University of São Paulo-Paulista School of Medicine - UNIFESP-EPM, São Paulo, Brazil. 4. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago - UIC, Chicago, IL, USA.
Abstract
OBJECTIVE: To compare the measurement of central thickness and depth of involvement of opacity-bearing corneas at different intensities (mild, moderate, and dense) using different instruments: Visante and Optovue OCTs, ultrasound biomicroscopy (UBM), and ultrasound pachymetry (central thickness). METHODS: Sample of 102 eyes: 70 eyes (68.63 %) with corneal opacity; 32 eyes (31.37%) with normal corneas. Corneal opacity grading included mild (28 eyes, 40.00 %), moderate (27 eyes, 37.57 %), and dense (15 eyes, 21.43 %). Opacity intensity was graded and documented. Central corneal thickness was determined using Optovue and Visante OCTs, ultrasound pachymetry, and UBM VuMax (50 MHz), and depth of corneal opacity, using Optovue and Visante OCTs and UBM. RESULTS: Total corneal thickness of the control group showed differences with a small correction factor using Optovue OCT (534.03 ± 39.88 μm), Visante OCT (523.72±38.70 μm), and ultrasound pachymetry (529.84 ± 39.76 μm), and were higher when compared to UBM (492.06 ± 37.93 μm). In mild opacity, depth measurements were the same with OCT Optovue and Visante and higher than those by UBM. In moderate opacities, there were no differences in measurements by different instruments. In dense opacities, OCT Optovue and Visante measurements were the same and higher than those by UBM. CONCLUSIONS: Central corneal thickness measurements were considered higher in corneas with opacity than in normal corneas. We observed that the greatest thicknesses were measured in corneas with dense opacities. There was a difference between the measurements taken by different instruments, both in central thickness and in opacity depth in cases of mild and dense opacity, and no difference in moderate opacity.
OBJECTIVE: To compare the measurement of central thickness and depth of involvement of opacity-bearing corneas at different intensities (mild, moderate, and dense) using different instruments: Visante and Optovue OCTs, ultrasound biomicroscopy (UBM), and ultrasound pachymetry (central thickness). METHODS: Sample of 102 eyes: 70 eyes (68.63 %) with corneal opacity; 32 eyes (31.37%) with normal corneas. Corneal opacity grading included mild (28 eyes, 40.00 %), moderate (27 eyes, 37.57 %), and dense (15 eyes, 21.43 %). Opacity intensity was graded and documented. Central corneal thickness was determined using Optovue and Visante OCTs, ultrasound pachymetry, and UBM VuMax (50 MHz), and depth of corneal opacity, using Optovue and Visante OCTs and UBM. RESULTS: Total corneal thickness of the control group showed differences with a small correction factor using Optovue OCT (534.03 ± 39.88 μm), VisanteOCT (523.72±38.70 μm), and ultrasound pachymetry (529.84 ± 39.76 μm), and were higher when compared to UBM (492.06 ± 37.93 μm). In mild opacity, depth measurements were the same with OCT Optovue and Visante and higher than those by UBM. In moderate opacities, there were no differences in measurements by different instruments. In dense opacities, OCT Optovue and Visante measurements were the same and higher than those by UBM. CONCLUSIONS: Central corneal thickness measurements were considered higher in corneas with opacity than in normal corneas. We observed that the greatest thicknesses were measured in corneas with dense opacities. There was a difference between the measurements taken by different instruments, both in central thickness and in opacity depth in cases of mild and dense opacity, and no difference in moderate opacity.
Authors: Yanni Wang; Gehua Ma; Guangzhi Gao; Ji Tao; Wenzhao Cao; Haohao Sun; Fengsen Ma; Yilong Zhang; Yen Wei; Mei Tian Journal: Research (Wash D C) Date: 2022-08-01