Ming Yang1, Jianghe Luo2, Qiaohong Yang3, Limian Xu4. 1. School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangzhou, China. Electronic address: hlym@gzucm.edu.cn. 2. School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangzhou, China. Electronic address: jiangheluo_gzucm@163.com. 3. School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangzhou, China. Electronic address: yangqiaohong@gzucm.edu.cn. 4. Department of Gynecology and Obstetrics, Affiliated Hospital 1, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangzhou, China. Electronic address: 13602706486@139.com.
Abstract
BACKGROUNDS: Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies. A variety of Chinese herbal medicines have shown good protective effects against TA. OBJECTIVE: To analyze the different prescriptions for TA and summarize the medication rules for such treatment. METHODS: Data mining methods including frequency analysis, cluster analysis, factor analysis and association rule learning were used in this study. RESULTS: In total, 171 herbs and 398 formulas were collected. The most frequently used herbs are Dipsaci Radix (Xuduan, accounts for 7.58%). The top three categories were deficiency-tonifying herbs (29.24%), wind-damp dispelling herbs (12.87%) and heat-clearing herbs (9.94%). Eleven factors and 8 clusters with clinical significance for prescription were formed by factor and cluster analyses. CONCLUSIONS: Tonification methods including spleen and kidney nourishment are the main principles for TA treatment and Shoutai Pill can be used as the basic formula for clinical addition or subtraction.
BACKGROUNDS: Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies. A variety of Chinese herbal medicines have shown good protective effects against TA. OBJECTIVE: To analyze the different prescriptions for TA and summarize the medication rules for such treatment. METHODS: Data mining methods including frequency analysis, cluster analysis, factor analysis and association rule learning were used in this study. RESULTS: In total, 171 herbs and 398 formulas were collected. The most frequently used herbs are Dipsaci Radix (Xuduan, accounts for 7.58%). The top three categories were deficiency-tonifying herbs (29.24%), wind-damp dispelling herbs (12.87%) and heat-clearing herbs (9.94%). Eleven factors and 8 clusters with clinical significance for prescription were formed by factor and cluster analyses. CONCLUSIONS: Tonification methods including spleen and kidney nourishment are the main principles for TA treatment and Shoutai Pill can be used as the basic formula for clinical addition or subtraction.