Kyriaki Seremidi1, Katerina Kavvadia2, Antonis Kattamis3, Argyro Polychronopoulou4. 1. Department of Pediatric Dentistry, Athens School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. 2. Division of Pediatric Dentistry, Department of Comprehensive Dentistry, University of Louisville, Louisville, KY, USA. 3. Division of Pediatric Haematology-Oncology, First Department of Paediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece. 4. Department of Preventive and Community Dentistry, Athens School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Abstract
BACKGROUND: Dental anomalies are common late side effects of childhood cancer therapy and may lead to anatomical, functional, and aesthetic sequelae. AIM: The study aimed to record dental late effects of antineoplastic treatment and associate them with disease and treatment characteristics in order to identify possible risk factors. DESIGN: Orthopantomograms of 70 survivors aged 4-21 years, who were treated at ages 0-10 years for any type of malignancy and completed antineoplastic treatment at least one year before, were examined. Incidence of developmental disturbances was recorded. Their severity was calculated, and odds ratios for the development of severe defects were estimated. RESULTS: Root defects presented in 62% of the participants, with impaired root growth being the most common (58%). Increased incidence was associated with combination treatment protocols, irradiation to the head and neck region, and administration of antimetabolites, steroids, and vincristine. Mean DeI value was 17.46 with risk factors for the development of severe root defects being diagnosis of acute lymphoblastic leukemia, combination treatment protocols, administration of cyclophosphamide and steroids, and hemopoietic stem cell transplantation. CONCLUSIONS: Root defects are common among childhood cancer survivors, with their incidence and severity being affected by multiple disease and treatment characteristics.
BACKGROUND:Dental anomalies are common late side effects of childhood cancer therapy and may lead to anatomical, functional, and aesthetic sequelae. AIM: The study aimed to record dental late effects of antineoplastic treatment and associate them with disease and treatment characteristics in order to identify possible risk factors. DESIGN: Orthopantomograms of 70 survivors aged 4-21 years, who were treated at ages 0-10 years for any type of malignancy and completed antineoplastic treatment at least one year before, were examined. Incidence of developmental disturbances was recorded. Their severity was calculated, and odds ratios for the development of severe defects were estimated. RESULTS: Root defects presented in 62% of the participants, with impaired root growth being the most common (58%). Increased incidence was associated with combination treatment protocols, irradiation to the head and neck region, and administration of antimetabolites, steroids, and vincristine. Mean DeI value was 17.46 with risk factors for the development of severe root defects being diagnosis of acute lymphoblastic leukemia, combination treatment protocols, administration of cyclophosphamide and steroids, and hemopoietic stem cell transplantation. CONCLUSIONS: Root defects are common among childhood cancer survivors, with their incidence and severity being affected by multiple disease and treatment characteristics.
Authors: Patrycja Proc; Joanna Szczepanska; Anna Herud; Malgorzata Zubowska; Wojciech Fendler; Monika Lukomska-Szymanska; Wojciech Mlynarski Journal: Int J Environ Res Public Health Date: 2022-03-29 Impact factor: 3.390